| Gene Symbol | GPT |
| Full Name | Alanine Transaminase |
| Aliases | Alanine Transaminase/ALT |
| Chromosome | 8q24.3 |
| Protein Type | Transferase |
| Function | Amino Acid Metabolism: ALT catalyzes the reversible transfer of amino groups between alanine and α-ketoglutarate, contributing to nitrogen metabolism and the urea cycle[^11]. |
| Primary Expression | the liver, with lower expression in kidney, heart, skeletal muscle, and brain tissue[^1] |
| Molecular Weight | 55 kDa |
| Amino Acids | 496 aa |
| Pathways | Ferroptosis, Lipid Metabolism, Proteasome, Ubiquitin-Proteasome |
| UniProt ID | [P24259](https://www.uniprot.org/uniprot/P24259) |
| Ensembl ID | ENSG00000149806 |
| OMIM | 613208 |
| GeneCards | GPT |
| Human Protein Atlas | GPT |
| Associated Diseases | Carcinoma, Hepatocellular Carcinoma |
| Interactions | ACTB, ATG, BECLIN1, BECN1, COL1A1, ELAVL1 |
| KG Connections | 67 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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