| Gene Symbol | GABRA1 |
| Chromosome | 5q34 |
| Protein Type | Ion Channel |
| Target Class | Ion Channel |
| Function | Positive allosteric modulator of GABA-A receptor |
| Mechanism of Action | GABRA1 mediates inhibitory neurotransmission through GABA-A receptor subunit composition, modulating neuronal excitability and synaptic signaling. In neurodegeneration contexts, alterations in GABRA1 expression or function can contribute to neuronal hyperexcitability, oxidative stress, and potentially accelerated cellular damage mechanisms associated with progressive neurological disorders. |
| Subcellular Localization | postsynaptic sites, where it clusters at synaptic junctions through interactions with gephyrin and other scaffold protei |
| Druggability | High (0.90) |
| Clinical Stage | Approved |
| Molecular Weight | 51 kDa |
| Amino Acids | 456 aa |
| Exons | 11 |
| Pathways | GABA-A receptor / inhibitory neurotransmission |
| UniProt ID | P14867 |
| GeneCards | GABRA1 |
| Human Protein Atlas | GABRA1 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | beta-sitosterol |
| Interactions | AMYLOID, AND, APOE, App, AQP4, C1Q |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Biorhythmic Interference via Controlled Sleep Osci |
| KG Connections | 298 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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