Clinical experiment designed to assess clinical efficacy targeting GABRA1, GABRG2 in human patient and Gabra1+/-/Gabrg2+/- mice. Primary outcome: seizure control
Treatment study evaluating the efficacy of phenobarbital as an anticonvulsant in both the mouse model and human patient. After multiple anti-seizure drugs failed in the patient, phenobarbital was found to be the most effective treatment for seizure control. This finding was validated in the mouse model, demonstrating translational relevance and providing therapeutic guidance for similar cases.
phenobarbital treatment with EEG monitoring
effective seizure control with phenobarbital
seizure reduction/control
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