gene 1,677 words KG: GABPA
Contents

GABPA - GA Binding Protein Transcription Factor Alpha Subunit

🧬 Gene Info
Gene SymbolGABPA
Full NameGA Binding Protein Transcription Factor Alpha Subunit
Chromosome21q21.3
Protein TypeTranscription Factor
Functionis a member of the ETS (E26 transformation-specific) family of transcription factors.
Molecular Weight51 kDa
Amino Acids454 aa
Exons11
PathwaysEpigenetic
UniProt IDQ06546
NCBI Gene ID2551
Ensembl IDENSG00000154727
OMIM137143
GeneCardsGABPA
Human Protein AtlasGABPA
Associated Diseasesneurodegeneration
InteractionsCANCER, EGFR, ERK1, KDM5C, MYC, TERT
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (6)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (8)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (10)

Neurodegeneration
disease · KG edge: implicated_in
Tumor Necrosis Factor (TNF)
entity · KG edge: inhibits
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
EGFR — Epidermal Growth Factor Receptor
gene · KG edge: activates
ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: activates

Knowledge Graph (11 edges)

KDM5C activates GABPA
MYC activates GABPA
EGFR activates GABPA
ERK1 activates GABPA
TERT activates GABPA
CANCER activates GABPA
GABPA activates Als
GABPA activates Cancer
GABPA inhibits Tumor
GABPA activates Glioblastoma

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