gene

KDM5C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM5C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

12Outgoing

0Incoming

0Experiments

0Debates

Summary

KDM5C is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Cancer, Glioblastoma. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	KDM5C
Full Name	Lysine Demethylase 5C
Chromosome	Xp11.22
Function	encodes an X-linked JmjC domain-containing histone demethylase that removes di- and trimethyl marks from histone H3 lysine 4 (H3K4me2/3).
Amino Acids	1560 aa
Pathways	Epigenetic, epigenetic regulation
UniProt ID	[P41229](https://www.uniprot.org/uniprot/P41229)
Ensembl ID	ENSG00000126012
GeneCards	KDM5C
Human Protein Atlas	KDM5C
JmjN + JmjC domains	Catalytic domains for Fe(II)/2-OG-dependent oxidative demethylation of H3K4me2/3
ARID domain	AT-rich interaction domain for DNA binding, directing KDM5C to specific genomic loci
PHD fingers (2x)	PHD1 reads H3K9me3, linking KDM5C to heterochromatin; PHD2 reads unmethylated H3K4, providing product recognition
C5HC2 zinc finger	Mediates interactions with transcriptional co-repressors including REST/NRSF and HDAC complexes
Enhancer decommissioning	KDM5C removes H3K4me3 from deactivating enhancers, converting them to poised (H3K4me1) state. Loss of KDM5C causes persistent "ghost" enhancers that drive spurious gene expression
Associated Diseases	neurodegeneration
Interactions	CANCER, EGFR, ERK1, GABPA, MYC, TERT
KG Connections	12 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KDM5C (Lysine Demethylase 5C)

gene · 1223 words

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Pathway Diagram

graph TD
    KDM5C["KDM5C"]
    Als{"Als"}
    KDM5C -->|"activates"| Als
    Cancer{"Cancer"}
    KDM5C -->|"activates"| Cancer
    Tumor{"Tumor"}
    KDM5C -->|"activates"| Tumor
    Glioblastoma{"Glioblastoma"}
    KDM5C -->|"activates"| Glioblastoma
    MYC["MYC"]
    KDM5C -->|"activates"| MYC
    EGFR["EGFR"]
    KDM5C -->|"activates"| EGFR
    CANCER["CANCER"]
    KDM5C -->|"activates"| CANCER
    ERK1["ERK1"]
    KDM5C -->|"activates"| ERK1
    TERT["TERT"]
    KDM5C -->|"activates"| TERT
    GABPA["GABPA"]
    KDM5C -->|"activates"| GABPA
    Epigenetic(["Epigenetic"])
    KDM5C -->|"activates"| Epigenetic
    neurodegeneration["neurodegeneration"]
    KDM5C -->|"implicated in"| neurodegeneration
    style KDM5C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Als	activates	disease	0.65
TERT	activates	gene	0.60
GABPA	activates	gene	0.60
CANCER	activates	gene	0.60
epigenetic regulation	participates_in	pathway	0.60
Epigenetic	activates	pathway	0.60
MYC	activates	gene	0.60
EGFR	activates	gene	0.60
ERK1	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDM5C in their description or question text

No additional research found