gene 2,790 words KG: PDIA3
Contents

PDIA3 - Protein Disulfide Isomerase Family A Member 3

🧬 Gene Info
Gene SymbolPDIA3
Full NameProtein Disulfide Isomerase Family A Member 3
AliasesPage for PDIA3
Chromosome15q15.3
Functionis a multifunctional endoplasmic reticulum (ER)-resident protein that plays critical roles in protein folding, redox homeostasis, calcium signaling, and cellular stress responses.
Molecular Weight57 kDa
Amino Acids505 aa
PathwaysAutophagy, Circadian Rhythm, Mtor, Nf-Κb
UniProt ID[P27773](https://www.uniprot.org/uniprot/P27773)
Ensembl IDENSG00000167077
GeneCardsPDIA3
Human Protein AtlasPDIA3
Associated Diseasesneurodegeneration
InteractionsAND, CLOCK, C-MYC, DNA, ERP57, MYC
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (5)

Circadian Clock-Autophagy Synchronization
Score: 0.76
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Temporal Decoupling via Circadian Clock Reset
Score: 0.54

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (13)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (10)

mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: activates
BMAL1 (ARNTL) Gene
gene · KG edge: regulates
CLOCK Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ERP57 activates PDIA3
PDIA3 interacts_with TGF-β
PDIA3 activates fibroblast activation
MTOR regulates PDIA3
MYC activates PDIA3
XPA activates PDIA3
CLOCK activates PDIA3
PDIA3 regulates BMAL1
PDIA3 regulates AHR
AHR regulates PDIA3

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