| Gene Symbol | EN2 |
| Protein Type | Transcription Factor |
| Function | Engrailed Homeobox 2 (EN2) is a member of the engrailed family of homeobox transcription factors that play critical roles in embryonic development, particularly in the central nervous system. |
| Primary Expression | the cerebellar plate and is crucial for Purkinje cell development and cerebellar foliation |
| Subcellular Localization | cytoplasm in some cell types, particularly during development |
| Amino Acids | 333 aa |
| GeneCards | EN2 |
| Human Protein Atlas | EN2 |
| Homeodomain | A 60-amino acid DNA-binding helix-turn-helix motif (positions 186-246) that recognizes and binds to specific DNA sequences (TAATTT) to regulate target gene transcription[@kissinger1990] |
| Harmonin homology domain | Involved in protein-protein interactions |
| Transactivation domain | Located at the N-terminus, responsible for activating transcription of target genes |
| Substantia nigra | High expression in dopaminergic neurons of the SNc |
| Ventral tegmental area | Expression in VTA dopaminergic neurons |
| Cerebellum | Expression in Purkinje cells and deep cerebellar nuclei |
| [Cortex](/brain-regions/cortex) | Expression in cortical layer 5 pyramidal neurons |
| Associated Diseases | neurodegeneration |
| Interactions | DAT, EN1, FOXA2, LMX1A, NURR1, PITX3 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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