| Gene Symbol | EN1 |
| Protein Type | Transcription Factor |
| Function | Engrailed Homeobox 1 (EN1) is a member of the engrailed family of homeobox transcription factors that play critical roles in embryonic development of the central nervous system. |
| Amino Acids | 391 aa |
| GeneCards | EN1 |
| Human Protein Atlas | EN1 |
| Homeodomain | A 60-amino acid DNA-binding helix-turn-helix motif (positions 240-300) that recognizes and binds to specific DNA sequences (TAATTT) to regulate target gene transcription[@gehring1994] |
| Harmonin homology domains | Involved in protein-protein interactions with other transcription factors |
| Transactivation domain | Located at the N-terminus, activates transcription of target genes |
| Substantia nigra pars compacta | High expression in dopaminergic neurons (highest expression of all EN family members in SNc) |
| Ventral tegmental area | Expression in VTA dopaminergic neurons |
| Red nucleus | Expression in midbrain motor neurons |
| Cerebellum | Expression in Purkinje cells during development |
| Olfactory bulb | Expression in interneurons |
| Associated Diseases | neurodegeneration |
| Interactions | DAT, EN2, FOXA2, LMX1A, NURR1, PITX3 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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