gene 2,995 words KG: CAV1
Contents

CAV1

🧬 Gene Info
Gene SymbolCAV1
AliasesCaveolin 1, Caveolin-1
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionNo established drugging mechanism for structural membrane protein
Mechanism of ActionNo established drugging mechanism for structural membrane protein
DruggabilityLow (0.35)
Clinical StageApproved
Molecular Weight22 kDa
PathwaysMAPK pathway, PI3K
UniProt IDQ2TNI1
GeneCardsCAV1
Human Protein AtlasCAV1
Associated DiseasesAls, Alzheimer, Anxiety, atherosclerosis
Known Drugs/CompoundsDaidzein
InteractionsABCB1, Actin, ADAMTS1, Adiponectin, AGO2, Akt
SciDEX TargetView Target Profile (1 clinical trials)
KG Connections501 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (29)

Lysosomal Positioning Dynamics Modulation
Score: 0.69
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Synthetic Biology Rewiring via Orthogonal Receptors
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.77
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54
← Prevpg 2/2

Related Analyses (10)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (15)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: contributes_to
ABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: activates
AGO2 (Argonaute-2)
gene · KG edge: interacts_with
Alzheimer Indonesia
institution · KG edge: regulates
ATG13 — Autophagy Related 13
gene · KG edge: activates

Knowledge Graph (12 edges)

TFR1 interacts_with CAV1
LRP1 interacts_with CAV1
CAV1 associated_with neurodegeneration
CAV1 interacts_with TFR1
CAV1 interacts_with LRP1
CAV1 interacts_with ABCB1
ABCB1 interacts_with CAV1
LRP1 co_discussed CAV1
LDLR co_discussed CAV1
TFR1 co_discussed CAV1

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