| Gene Symbol | C1QA |
| Full Name | Complement Component 1, Q Subunit A |
| Chromosome | 1p36.33 |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | The C1QA gene encodes the A-chain of complement component C1q. |
| Mechanism of Action | Complement cascade inhibitor or antibody-mediated neutralization |
| Primary Expression | Primarily expressed in myeloid cells (monocytes, macrophages, microglia); astrocytic expression detected in disease states |
| Subcellular Localization | synapses, dystrophic neurites, extracellular protein aggregates, and vascular interfaces. These features make C1QA a hig |
| Druggability | Low (0.41) |
| Clinical Stage | Phase II |
| Amino Acids | 245 aa |
| Pathways | Complement, Complement system, Synaptic pruning, complement activation |
| UniProt ID | P02787 |
| NCBI Gene ID | 712 |
| Ensembl ID | ENSG00000196954 |
| OMIM | 120550 |
| GeneCards | C1QA |
| Human Protein Atlas | C1QA |
| Associated Diseases | A1_astrocytes, AD, Aging, ALI, Als |
| Known Drugs/Compounds | C1q_mimetic_decoys |
| Interactions | AIF1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, ANXIETY |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | Complement C1q Mimetic Decoy Therapy Complement C1QA Spatial Gradient in Cortical Layer Complement C1q Subtype Switching (+5 more) |
| KG Connections | 721 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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