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gene 757 words KG: BAG2
Contents

BAG2

🧬 Gene Info
Gene SymbolBAG2
Protein TypeChaperone
FunctionBAG2 (BCL2 Associated Athanogene 2) is a co-chaperone protein that modulates the Hsp70/Hsp90 chaperone systems.
Molecular Weight22.5 kDa
Amino Acids211 aa
PathwaysProteasome
Ensembl IDENSG00000165168
GeneCardsBAG2
Human Protein AtlasBAG2
IPO2005 (TSE: 4568)
Market Cap~$70B (2026)
2025 Revenue¥1.5T
Associated DiseasesMs
InteractionsAUTOPHAGY, P62, SQSTM1, TAU, UBIQUITIN
KG Connections16 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (9)

Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72Cross-Seeding Prevention Strategy
Score: 0.69Glycine-Rich Domain Competitive Inhibition
Score: 0.64Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Ubiquitin-Proteasome System Therapeutic Companies for P
company · KG edge: activatesNeurodegeneration
disease · KG edge: implicated_inAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: inhibitsProteasome-Ubiquitin System Dysfunction Validation in P
experiment · KG edge: activatesBCL2 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

BCL2 associated_with BAG2
BAG2 interacts_with SQSTM1
BAG2 interacts_with P62
SQSTM1 interacts_with BAG2
P62 interacts_with BAG2
BAG2 associated_with BCL2
HSP70 associated_with BAG2
TAU activates BAG2
UBIQUITIN activates BAG2
BAG2 associated_with Ms

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