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mechanism 901 words KG: FOXO
Contents

FOXO Signaling Pathway in Neurodegeneration

⚙ Mechanism Info
NameFOXO
Key Genes/ProteinsActin, AGING, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
Related DiseasesAging, Als, ALS, Alzheimer, Amyotrophic Lateral Sclerosis
Related Pathwaysadipogenesis, Ampk Signaling
Linked Hypotheses4 hypotheses

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Knowledge Graph

Related Hypotheses (6)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A
Score: 0.79FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Unde
Score: 0.70FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.67Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60Epigenetic Memory Reprogramming via CRISPRa-Mediated Chromat
Score: 0.54

Knowledge Graph (12 edges)

AMPK interacts_with FOXO
AMPK activates FOXO
SIRT1 activates FOXO
FOXO inhibits adipogenesis
FOXO activates apoptosis
FOXO activates FAS
FOXO activates BCL2L1
FOXO activates BNIP3
FOXO activates BCL2L11
AKT inhibits FOXO

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