| Gene Symbol | CCNF |
| Aliases | Cyclin F |
| Function | Ccnf Protein (Cyclin F) plays an important role in the study of neurodegenerative diseases |
| Primary Expression | most tissues, with highest expression in: |
| Subcellular Localization | </th><td>Nucleus, Cytoplasm</td></tr> |
| Molecular Weight | 89.5 kDa |
| Amino Acids | 786 aa |
| Pathways | Apoptosis, Cell Cycle, apoptosis |
| GeneCards | CCNF |
| Human Protein Atlas | CCNF |
| N-terminal Domain | Contains regulatory elements including phosphorylation sites that modulate protein-protein interactions and substrate binding affinity. |
| C-terminal Regions | House additional protein interaction motifs and post-translational modification sites. |
| Phosphorylation | Multiple serine/threonine phosphorylation sites regulate substrate binding and SCF complex assembly. Casein kinase 2 (CK2) phosphorylation enhances CCNF activity[@shimizu2018]. |
| Ubiquitination | As an E3 ligase, CCNF itself can be ubiquitinated, leading to proteasomal degradation in a feedback regulatory mechanism. |
| Sumoylation | SUMO modification influences nuclear-cytoplasmic trafficking and protein stability. |
| Associated Diseases | frontotemporal dementia |
| Interactions | ALS, APOPTOSIS, CDKN1A, CHCHD10, MATR3, NEK1 |
| KG Connections | 111 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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