biomarker 1,403 words KG: CLUSTERIN
Contents

Clusterin (ApoJ) - AD Biomarker

🔬 Protein Info
Gene SymbolCLU
Full NameClusterin
AliasesPage for CLU Gene
Chromosome8p21.1.
Protein FamilyApolipoprotein / extracellular chaperone
FunctionIt binds to non-native, misfolded, or aggregation-prone proteins and maintains them in a soluble state suitable for subsequent processing (Wyatt et al., 2009)
Primary ExpressionSecreted (sCLU), cytoplasmic/nuclear (nCLU/iCLU)
Molecular Weight80 kDa
Amino Acids522 aa
Exons9
PathwaysApoptosis, Complement, Immune Response, Mitophagy
UniProt IDP10909
NCBI Gene ID1115
Ensembl IDENSG00000120885
OMIM185551
GeneCardsCLU
Human Protein AtlasCLU
Associated Diseasesaging, Als, Alzheimer, Alzheimer Disease
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, Amyloid Beta, APOE
KG Connections281 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (49)

Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Circadian Rhythm Entrainment of Reactive Astrocytes
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Membrane Cholesterol Gradient Modulators
Score: 0.71
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Axonal RNA Transport Reconstitution
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
← Prevpg 2/3Next →

Related Analyses (26)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (8)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40
iPSC-NPC effects on astrocytes in vitro ICH model
exploratory · completed · Score: 0.90
Blood Biomarker vs Tau PET for Treatment Monitoring
clinical · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40

See Also (11)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: activates
BACE1 (Redirect)
redirect · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates

Knowledge Graph (12 edges)

CLU regulates CLUSTERIN
PPARGC1A regulates CLUSTERIN
BAX activates CLUSTERIN
CLUSTERIN activates LC3
CLUSTERIN regulates PPARG
C1S regulates CLUSTERIN
CLUSTERIN activates C1Q
CLUSTERIN regulates CR1
CLUSTERIN associated_with CFH
PPARG regulates CLUSTERIN

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