| Gene Symbol | amyloid |
| CSF Aβ40 | Decreased (~20-30% reduction) due to amyloid plaque sequestration[^2] in the brain |
| Plasma Aβ40 | Variable; may be increased (reflecting overproduction) or decreased (reflecting peripheral clearance) |
| Aβ40 production | ~1-2 ng/day in normal adult brain[^4] |
| Aβ40/P-tau ratio | Improved diagnostic utility over Aβ40 alone |
| Aβ42/Aβ40 ratio | Lower in AD vs healthy controls |
| Associated Diseases | Alzheimer's disease, circuit instability, cognitive deficits, neurodegeneration, SST/PV interneuron alterations |
| KG Connections | 26 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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