concept

B4GALNT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B4GALNT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

0Hypotheses

1Analyses

43Outgoing

6Incoming

0Experiments

1Debates

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💡 Concept Info

Name	B4GALNT1
Key Genes/Proteins	App, ATXN3, BST1, COMPLEMENT, CR2, ERBB1
Related Diseases	Als, ALS, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Related Pathways	Complement, ganglioside synthesis

Pathway Diagram

graph TD
    B4GALNT1["B4GALNT1"]
    B4GALNT1 -->|"catalyzes"| Ganglioside_Synthesis["Ganglioside Synthesis"]
    B4GALNT1 -->|"product_of"| Gangliosides["Gangliosides"]
    B4GALNT1 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    B4GALNT1 -->|"regulates"| ALS["ALS"]
    B4GALNT1 -->|"regulates"| Inflammation["Inflammation"]
    B4GALNT1 -->|"regulates"| Als["Als"]
    B4GALNT1 -->|"regulates"| ST8SIA1["ST8SIA1"]
    B4GALNT1 -->|"regulates"| JUN["JUN"]
    NEURODEGENERATION["NEURODEGENERATION"] -->|"regulates"| B4GALNT1
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| B4GALNT1
    COMPLEMENT["COMPLEMENT"] -->|"regulates"| B4GALNT1
    ST8SIA1 -->|"regulates"| B4GALNT1
    JUN -->|"regulates"| B4GALNT1

Outgoing (43)

Target	Relation	Type	Str
Ganglioside Synthesis	catalyzes	process	0.90
Gangliosides	product_of	compound	0.85
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.80
ganglioside synthesis	regulates	pathway	0.70
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
GPNMB	causes	gene	0.60
IL34	causes	gene	0.60
PILRA	causes	gene	0.60
SHARPIN	causes	gene	0.60
STX6	causes	gene	0.60
TREM2	causes	gene	0.60
Alzheimer's disease	causes	disease	0.60
Parkinson's disease	causes	disease	0.60
neurodegeneration	causes	disease	0.60
ALS	causes	disease	0.60
ST8SIA1	regulates	gene	0.60
JUN	regulates	gene	0.60
NEURON	associated_with	gene	0.60
Complement	regulates	pathway	0.60
BST1	causes	gene	0.60
CR2	causes	gene	0.60
ERBB1	causes	gene	0.60
Neuron	associated_with	cell_type	0.60
COMPLEMENT	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
Leptin	regulates	protein	0.60
INFLAMMATION	regulates	gene	0.60
Raf	regulates	protein	0.60
Sumo	regulates	protein	0.60
Ras	regulates	protein	0.60
App	regulates	protein	0.60
oxidative stress response	participates_in	pathway	0.60
Thalamus	expressed_in	brain_region	0.55
Hypothalamus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
Alzheimer's disease	interacts_with	disease	0.55
lipid metabolism	participates_in	pathway	0.55
sphingolipid metabolism	participates_in	pathway	0.55
ST3GAL5	activates	gene	0.55
ST3GAL2	interacts_with	gene	0.55

Incoming (6)

Source	Relation	Type	Str
JUN	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
ATXN3	causes	gene	0.60
ST8SIA1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms determine the conformational diversity and strain-like

neurodegeneration | 2026-04-07 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract mentions that pathological seeds have different characteristics and

closed · Rounds: 4 · Score: 0.65 · 2026-04-21

Related Research

Hypotheses and analyses mentioning B4GALNT1 in their description or question text

No additional research found