| Gene Symbol | SLC7A11 |
| Full Name | Solute Carrier Family 7 Member 11 (xCT) |
| Chromosome | 4q28.3 |
| Protein Type | Transporter |
| Target Class | Transporter |
| Function | Small molecule inhibition of cystine/glutamate exchange |
| Mechanism of Action | Small molecule inhibition of cystine/glutamate exchange |
| Primary Expression | various brain cell types: |
| Druggability | Medium (0.55) |
| Clinical Stage | Approved |
| Pathways | Akt, Autophagy, Epigenetic, Ferroptosis, Glutathione Biosynthesis |
| UniProt ID | Q9UPY5 |
| Ensembl ID | ENSG00000155511 |
| GeneCards | SLC7A11 |
| Human Protein Atlas | SLC7A11 |
| Associated Diseases | Als, cancer, Carcinoma |
| Known Drugs/Compounds | alphaKG, curcumin, CURCUMIN, icariin, kynurenine, NICOTINAMIDE |
| Interactions | ACETYL-COA, ACSL4, AGING, AKT, ALOX, ALOX12 |
| SciDEX Target | View Target Profile (4 clinical trials) |
| SciDEX Hypotheses | Microglial xCT/SLC7A11 Selective Inhibition to Red |
| KG Connections | 1410 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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