| Gene Symbol | KCNK2 |
| Full Name | Potassium Two Pore Domain Channel Subfamily K Member 2 |
| Aliases | TREK-1, TASK-1 Potassium Channel |
| Chromosome | 1q41 |
| Protein Type | Ion Channel |
| Target Class | Ion Channel |
| Function | Small molecule channel modulation |
| Mechanism of Action | KCNK2 encodes a two-pore domain potassium channel (TREK-1) that regulates neuronal excitability, membrane potential, and cellular responsiveness to mechanical and chemical stimuli in the central nervous system. In neurodegeneration, TREK-1 modulation can influence neuronal survival, mitochondrial function, and potentially mitigate oxidative stress and excitotoxicity through precise potassium conductance regulation. |
| Subcellular Localization | somatodendritic compartments |
| Druggability | Medium (0.58) |
| Clinical Stage | Approved |
| Molecular Weight | 56 kDa |
| Pathways | Membrane Potential |
| UniProt ID | O95069 |
| NCBI Gene ID | 5136 |
| Ensembl ID | ENSG00000024048 |
| OMIM | 607412 |
| GeneCards | KCNK2 |
| Human Protein Atlas | KCNK2 |
| Associated Diseases | Als, ANTIDEPRESSANT_RESPONSE, Autoimmune, Cancer, depression |
| Known Drugs/Compounds | BL1249, DEX, ML335, ML-402, Spadin |
| Interactions | AND, ANG, APOPTOSIS, App, C1Q, CANCER |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Aquaporin-4 Polarization Enhancement via TREK-1 Ch |
| KG Connections | 495 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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