Contents

CLOCK Gene

🧬 Gene Info

Gene Symbol	CLOCK
Full Name	Circadian Locomotor Output Cycles Kaput
Chromosome	4q12
Protein Type	Transcription Factor
Target Class	Transcription Factor
Function	CLOCK is a bHLH-PAS transcription factor that functions as the master regulator of the circadian clock.
Mechanism of Action	Modulation of circadian transcriptional activity through protein-protein interaction disruption
Druggability	Low (0.35)
Clinical Stage	Approved
Pathways	Akt, Amyloid, Apoptosis, Autophagy, CIRCADIAN_RHYTHM
UniProt ID	O15516
NCBI Gene ID	9609
Ensembl ID	ENSG00000132266
OMIM	601851
GeneCards	CLOCK
Human Protein Atlas	CLOCK
Associated Diseases	aging, Als, Alzheimer
Known Drugs/Compounds	nicotinamide
Interactions	ACETYL-COA, Actin, AGING, AHR, AKT, ALOX12
SciDEX Target	View Target Profile (10 clinical trials)
SciDEX Hypotheses	Circadian Clock-Autophagy Synchronization Temporal Decoupling via Circadian Clock Reset
KG Connections	1347 knowledge graph edges
Databases	GeneCards HPA STRING

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