LOX

Lysyl oxidase

Score: 0.593 Price: $0.59 Low Druggability Status: active Wiki: LOX

🧠 Neurodegeneration

HYPOTHESES

PAPERS

KG EDGES

774

DEBATES

3D Protein Structure

🧬 LOX — PDB 5SOR Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Druggability & Clinical Context

Druggability

Low

Score: 0.43

Clinical Stage

Phase II

Target Class

Enzyme

Safety

0.50

Druggability Analysis

Drug Development0.30

Structural Tractability0.70

Target Class0.85

Safety Profile0.50

Key Metrics

PDB Structures:

Known Drugs:

Approved:

In Clinical Trials:

Drug Pipeline (1 compounds)

Druggability Rationale: LOX (lysyl oxidase) represents a moderately promising neurodegeneration drug target with medium druggability, primarily due to its critical role in extracellular matrix remodeling and crosslinking. The availability of structural data and existing small molecule inhibition strategies like simtuzumab suggest potential therapeutic approaches, though significant additional validation would be required to establish neurodegeneration-specific efficacy. Structural insights from PDB entries and AlphaFold predictions provide a foundation for rational drug design targeting its enzymatic active site.

Mechanism: Small molecule inhibition of lysyl oxidase enzymatic activity

Drug Pipeline (1 compounds)

Known Drugs:

Simtuzumab (Clinical) — Fibrotic diseases

Structural Data:

PDB (3) ✓AlphaFold ✓Cryo-EM —

4G32 4G33 4RPE

UniProt: B7ZAJ4

🧬 3D Protein Structure

🧬 LOX — PDB 5SOR Click to expand interactive 3D viewer

Experimental structure from RCSB PDB | Powered by Mol* | Rotate: click+drag | Zoom: scroll

Selectivity & Safety Considerations

LOX shares structural homology with the copper-dependent amine oxidase family (LOX-like proteins: LOXL1-4), presenting significant isoform selectivity challenges for small molecule inhibitors. Off-target inhibition of monoamine oxidases (MAO-A/B) and other oxidative enzymes must be carefully monitored, particularly in CNS applications where neurochemical balance is critical.