protein

PHOSPHO-TAU

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHOSPHO-TAU: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

1Hypotheses

0Analyses

14Outgoing

24Incoming

0Experiments

0Debates

Summary

Phosphorylated Tau Protein

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🔬 Protein Info

Gene Symbol	PHOSPHO
Function	Phosphorylated tau (p-tau) refers to the hyperphosphorylated form of the microtubule-associated protein tau (MAPT)
GeneCards	PHOSPHO
Human Protein Atlas	PHOSPHO
Associated Diseases	Alzheimer'S Disease, disease
Interactions	APOE, RETROMER, SORL1
KG Connections	32 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["PHOSPHO-TAU"]
    N1["Neuron"]
    N0 -->|"activates"| N1
    N2["NEURONS"]
    N0 -->|"activates"| N2
    N3["AMYLOID"]
    N0 -->|"protects against"| N3
    N0 -->|"expressed in"| N3
    N4["SYNUCLEIN"]
    N0 -->|"expressed in"| N4
    N5["NEUROFIBRILLARY TANGLES"]
    N0 -->|"expressed in"| N5
    N6["ALZHEIMER"]
    N0 -->|"associated with"| N6
    N7["Alzheimer'S Disease"]
    N0 -->|"associated with"| N7
    N8["disease"]
    N0 -->|"associated with"| N8
    N9["ALZHEIMER'S"]
    N0 -->|"associated with"| N9
    N10["CEREBROSPINAL FLUID"]
    N0 -->|"associated with"| N10
    N11["APOE"]
    N11 -->|"activates"| N0
    N12["Autophagy"]
    N12 -->|"activates"| N0
    N13["SORL1"]
    N13 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N3 gene
    class N6 gene
    class N7 disease
    class N8 disease
    class N11 gene
    class N13 gene

Outgoing (14)

Target	Relation	Type	Str
Neuron	activates	cell_type	0.50
NEURONS	activates	concept	0.50
AMYLOID	protects_against	gene	0.50
AMYLOID	expressed_in	gene	0.50
SYNUCLEIN	expressed_in	concept	0.50
NEUROFIBRILLARY TANGLES	expressed_in	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
CEREBROSPINAL FLUID	associated_with	concept	0.50
CA1	associated_with	brain_region	0.50
CORTEX	associated_with	brain_region	0.50
AMYLOID PET	associated_with	biomarker	0.50

Incoming (24)

Source	Relation	Type	Str
Strem2	correlates_with	protein	0.92
AUTOPHAGY	modulates	process	0.85
SV2A	correlates_with	protein	0.85
Retromer-Mediated Trafficking	modulates	process	0.85
SORL1	regulates	gene	0.80
MTOR	inhibits_removal_of	gene	0.80
NEURONS	causes	cell_type	0.70
NEURONS	treats	cell_type	0.70
MICROGLIA	causes	cell_type	0.70
MICROGLIA	destabilizes	cell_type	0.70
GSK3β	activates	protein	0.70
AUTOPHAGY	treats	phenotype	0.65
TAU	targets	protein	0.60
RETROMER	activates	protein	0.50
SORL1	activates	gene	0.50
Autophagy	activates	process	0.50
INSULIN SIGNALING	associated_with	pathway	0.50
APOE	activates	gene	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.50
Alpha-Synuclein	expressed_in	protein	0.50
AMYLOID-BETA	expressed_in	protein	0.50
TREM2	associated_with	gene	0.50
NEUROFILAMENT LIGHT	associated_with	biomarker	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
A post-trigger CDK5-dominant kinase feedback loop maintains	0.590	neurodegeneration	Does tau dendritic missorting persist in

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PHOSPHO-TAU in their description or question text

No additional research found