protein

RETROMER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RETROMER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

36Connections

7Hypotheses

0Analyses

23Outgoing

13Incoming

0Experiments

0Debates

Summary

Page for Retromer Protein

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	RETROMER
Function	The Retromer Complex is a vital coat protein complex that mediates retrograde transport from endosomes to the trans-Golgi network (TGN), playing a fundamental role in intracellular protein traffick...
Amino Acids	728 aa
GeneCards	RETROMER
Human Protein Atlas	RETROMER
Interactions	ALZHEIMER, AMYLOID, APOE, APP, NEURON, PARKINSON
KG Connections	36 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    RETROMER["RETROMER"]
    NEURON["NEURON"]
    RETROMER -->|"activates"| NEURON
    SORL1["SORL1"]
    RETROMER -->|"activates"| SORL1
    APP["APP"]
    RETROMER -->|"activates"| APP
    RAB7A["RAB7A"]
    RETROMER -->|"activates"| RAB7A
    NF__B["NF-kappaB"]
    RETROMER -->|"activates"| NF__B
    Genes["Genes"]
    RETROMER -->|"activates"| Genes
    GENETIC_MODIFIERS["GENETIC MODIFIERS"]
    RETROMER -->|"activates"| GENETIC_MODIFIERS
    PHOSPHO_TAU["PHOSPHO-TAU"]
    RETROMER -->|"activates"| PHOSPHO_TAU
    Neuron["Neuron"]
    RETROMER -->|"activates"| Neuron
    NEURONS["NEURONS"]
    RETROMER -->|"activates"| NEURONS
    aging["aging"]
    RETROMER -->|"interacts with"| aging
    ENDOSOMES["ENDOSOMES"]
    RETROMER -->|"interacts with"| ENDOSOMES
    ALZHEIMER["ALZHEIMER"]
    RETROMER -->|"interacts with"| ALZHEIMER
    PARKINSON["PARKINSON"]
    RETROMER -->|"interacts with"| PARKINSON
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    RETROMER -->|"interacts with"| Alzheimer_S_Disease
    Genes["Genes"]
    RETROMER -->|"interacts with"| Genes
    Parkinson_s_Disease["Parkinson's Disease"]
    RETROMER -->|"interacts with"| Parkinson_s_Disease
    Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    RETROMER -->|"interacts with"| Neurodegenerative_Diseases
    disease["disease"]
    RETROMER -->|"interacts with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    RETROMER -->|"interacts with"| ALZHEIMER_S
    PARKINSON_S["PARKINSON'S"]
    RETROMER -->|"interacts with"| PARKINSON_S
    FRONTOTEMPORAL["FRONTOTEMPORAL"]
    RETROMER -->|"interacts with"| FRONTOTEMPORAL
    AMYLOID["AMYLOID"]
    RETROMER -->|"interacts with"| AMYLOID
    ENDOSOME["ENDOSOME"]
    RETROMER -->|"interacts with"| ENDOSOME
    Neuron["Neuron"]
    RETROMER -->|"inhibits"| Neuron
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| RETROMER
    GENES["GENES"]
    GENES -->|"co discussed"| RETROMER
    AMYLOID["AMYLOID"]
    AMYLOID -->|"inhibits"| RETROMER
    SORL1["SORL1"]
    SORL1 -->|"inhibits"| RETROMER
    NEURON["NEURON"]
    NEURON -->|"co discussed"| RETROMER

Outgoing (23)

Target	Relation	Type	Str
NEURON	activates	gene	0.50
SORL1	activates	gene	0.50
APP	activates	gene	0.50
GENETIC MODIFIERS	activates	concept	0.50
RAB7A	activates	protein	0.50
NF-κB	activates	concept	0.50
PHOSPHO-TAU	activates	protein	0.50
Neuron	activates	cell_type	0.50
NEURONS	activates	concept	0.50
aging	interacts_with	phenotype	0.50
ENDOSOMES	interacts_with	concept	0.50
ALZHEIMER	interacts_with	gene	0.50
PARKINSON	interacts_with	gene	0.50
Alzheimer'S Disease	interacts_with	disease	0.50
Parkinson's Disease	interacts_with	disease	0.50
Neurodegenerative Diseases	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
ALZHEIMER'S	interacts_with	concept	0.50
PARKINSON'S	interacts_with	concept	0.50
FRONTOTEMPORAL	interacts_with	concept	0.50
AMYLOID	interacts_with	gene	0.50
ENDOSOME	interacts_with	concept	0.50
Neuron	inhibits	cell_type	0.50

Incoming (13)

Source	Relation	Type	Str
VPS29	activates	gene	0.50
ALZHEIMER	activates	gene	0.50
GENES	co_discussed	gene	0.50
AMYLOID	inhibits	gene	0.50
SORL1	inhibits	gene	0.50
NEURON	co_discussed	gene	0.50
TBK1	activates	gene	0.50
APOE	activates	gene	0.50
Autophagy	activates	process	0.50
SORL1	activates	gene	0.50
Neurodegeneration	interacts_with	disease	0.50
SORL1	interacts_with	gene	0.50
SORL1	associated_with	gene	0.50

Targeting Hypotheses (7)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VPS35 retromer activation prevents endosomal tau templating	0.740	neurodegeneration	Which tau propagation mechanism predomin
Glucosylceramide Accumulation from GCase Deficiency Disrupts	0.700	neurodegeneration	-
VPS35 Retromer Dysfunction Creates a GCase Trafficking Bottl	0.700	neurodegeneration	-
Retromer-dependent retrograde endosomal signaling compartmen	0.645	neuroscience	How can subcellular compartmentalization
VPS35 Retromer Restoration to Rescue Endosomal Protein Traff	0.525	proteomics	Quantitative proteomics of the aging syn

TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysos	0.510	proteomics	Quantitative proteomics of the aging syn
VPS26A Subunit Enhancement to Stabilize Retromer Complex Ass	0.471	proteomics	Quantitative proteomics of the aging syn

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (8)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Extracellular vesicles from IPFP-MSCs trigger osteoarthritis by transferring mtD [PMID:41480405]	Li S, Yan Z, Zhi X, Zheng W, Zhang Z et	Bioact Mater	2026
Comprehensive multi-omics analysis and experimental validation indicate that VPS [PMID:41531939]	Wan D, Qi Y, Kang Y, Liang F, Wang Q et	RSC Med Chem	2026
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026
VPS35 Deficiency Markedly Reduces the Proliferation of HEK293 Cells. [PMID:41751560]	Lee S, Park S, Bang H, Kim SU, Park YH e	Genes (Basel)	2026
N-acetyl-l-leucine lowers α-synuclein levels and improves synaptic function in P [PMID:41766663]	Song P, Chen C, Franchini R, Duong B, Wa	J Clin Invest	2026
The VPS35 protein and the role of its impairments in mitochondrial dysfunction i [PMID:41841708]	Buneeva OA, Medvedev AE	Biomed Khim	2026
Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation [PMID:41846978]	Deng IB, Bu M, Follett J, Sharp R, Mamai	bioRxiv	2026
Lack of Cerebrospinal Fluid α-Synuclein Seeding in VPS35 D620N- and LRRK2 Y1699C [PMID:41912440]	Santinelli L, Pratuseviciute N, Lange LM	Mov Disord	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RETROMER in their description or question text

TFEB-Mediated Retromer Biogenesis to Restore Endosomal-Lysosomal Trafficking in

Score: 0.510 · proteomics · 2026-04-26

This hypothesis proposes that TFEB activation can restore synaptic function in aging by simultaneously upregulating both

VPS26A Subunit Enhancement to Stabilize Retromer Complex Assembly

Score: 0.471 · proteomics · 2026-04-26

This hypothesis proposes that targeted enhancement of VPS26A subunit expression and stability can rescue retromer comple