concept

FBL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FBL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

36Outgoing

4Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FBL
Key Genes/Proteins	ALS
Related Diseases	Als/Ftd, ALS/FTD, Alzheimer's disease, Alzheimer's Disease, Alzheimer'S Disease
Related Pathways	apoptosis pathway, Cellular Stressors

Pathway Diagram

graph TD
    FBL[FBL]
    FBL -->|involved_in| Ribosome_Biogenesis[Ribosome Biogenesis]
    FBL -->|contributes to| ALS_FTD[ALS/FTD]
    FBL -->|regulates| ribosome_biogenesis[ribosome biogenesis]
    FBL -->|contributes to| Alzheimer_S_Disease[Alzheimer'S Disease]
    FBL -->|regulates| Apoptosis[Apoptosis]
    FBL -->|mediates| apoptosis[apoptosis]
    FBL -->|activates| TP53[TP53]
    FBL -->|regulates| rRNA_processing[rRNA processing]
    FBL -->|regulates| Rrna_Processing[Rrna Processing]
    cellular_stressors[cellular stressors] -->|modulates| FBL
    Cellular_Stressors[Cellular Stressors] -->|modulates| FBL
    ALS[ALS] -->|activates| FBL

Outgoing (36)

Target	Relation	Type	Str
h-b2fd6e79d1	targeted_by	hypothesis	1.00
Alzheimer'S Disease	contributes_to	disease	0.95
Apoptosis	regulates	process	0.95
apoptosis	mediates	process	0.95
Ribosome Biogenesis	involved_in	process	0.95
ALS/FTD	contributes_to	disease	0.95
ribosome biogenesis	regulates	process	0.95
Nucleolar Stress Response	regulates	pathway	0.90
Rrna Processing	regulates	process	0.90
rRNA processing	regulates	process	0.90
Ribosome Biogenesis	regulates	process	0.90
TP53	activates	gene	0.90
Neurodegeneration	involved_in	disease	0.90
Neurodegeneration	implicated_in	disease	0.85
Cancer	associated_with	disease	0.85
Neuronal Death	causes	phenotype	0.85
apoptosis resistance	promotes	phenotype	0.80
Als/Ftd	contributes_to	disease	0.80
Alzheimer's Disease	contributes_to	disease	0.80
Alzheimer's Disease	implicated_in	disease	0.75
Als/Ftd	implicated_in	disease	0.75
translational control	modulates	process	0.75
TP53	interacts_with	protein	0.70
breast cancer	associated_with	disease	0.70
hepatocellular carcinoma	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
apoptosis	regulates	process	0.70
RNA	inhibits	gene	0.60
frontotemporal dementia	activates	disease	0.60
Alzheimer's disease	activates	disease	0.60
apoptosis pathway	participates_in	pathway	0.60
neurodegeneration	associated_with	disease	0.60
MDM2	activates	gene	0.60
neurodegeneration	regulates	disease	0.60
oxidative stress response	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60

Incoming (4)

Source	Relation	Type	Str
h-b2fd6e79d1	targets	hypothesis	1.00
cellular stressors	modulates	process	0.80
Cellular Stressors	modulates	mechanism	0.80
ALS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FBL in their description or question text

No additional research found