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mechanism 1,494 words KG: AD
Contents

Neuronal Death Pathways in Alzheimer's Disease

⚙ Mechanism Info
NameAD
Key Genes/ProteinsA2M, AB, ABCA1, ABCB1, ABCD3, ABCG1
Related DiseasesAGE
Linked Hypotheses118 hypotheses

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Wikipedia

Related Hypotheses (131)

Closed-loop optogenetic targeting PV interneurons to restore
Score: 0.95Closed-loop focused ultrasound targeting EC-II PV interneuro
Score: 0.86Closed-loop tACS targeting EC-II parvalbumin interneurons to
Score: 0.85Real-time gamma-guided transcranial focused ultrasound targe
Score: 0.83Neutrophil Extracellular Trap (NET) Inhibition
Score: 0.81CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind
Score: 0.80NMN Supplementation Restores SIRT1/p66Shc/FOXO3 Epigenetic A
Score: 0.79PINK1/Parkin–TREM2 Axis: Convergent Mitophagy Failure Unifie
Score: 0.78ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v
Score: 0.77H3: SIRT1 Insufficiency Disconnects Metabolic Sensing from E
Score: 0.77Closed-loop tACS targeting EC-II PV interneurons to suppress
Score: 0.76Synaptic Vesicle Cycle Hijacking: Shared Convergent Mechanis
Score: 0.76PARP1-NAD+-AIF bioenergetic collapse drives a self-amplifyin
Score: 0.76Night-phase orexin receptor antagonism rescues AD by restori
Score: 0.76Senescence-Activated NAD+ Depletion Rescue
Score: 0.76Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove
Score: 0.75Metabolic Inflexibility Precedes Transcriptional Reprogrammi
Score: 0.73Adenosine-Astrocyte Metabolic Reset
Score: 0.73Selective LXRβ agonists restore ABCA1/ABCG1 expression and A
Score: 0.73Closed-loop focused ultrasound targeting CA1 PV interneurons
Score: 0.72
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Knowledge Graph (12 edges)

GSS implicated_in AD
CYP2E1 implicated_in AD
IDH2 implicated_in AD
IDH1 implicated_in AD
VEGFA implicated_in AD
EEF1A1 implicated_in AD
APOB implicated_in AD
MET implicated_in AD
MCL1 implicated_in AD
SF3B1 implicated_in AD

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