gene

TUBB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUBB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

12Outgoing

18Incoming

0Experiments

0Debates

Summary

TUBB1 encodes beta-tubulin isotype 1, a core component of microtubules critical for cytoskeletal structure, axonal transport, and platelet formation. Dysregulation implicated in AD, PD, and peripheral neuropathy.

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🧬 Gene Info

Gene Symbol	TUBB1
Full Name	Tubulin Beta 1
Chromosome	9q34.3
Function	is a gene located on chromosome 9q34.
Primary Expression	megakaryocytes and platelets, it is also expressed in neurons where it contributes to microtubule assembly, axonal transport, and cytoskeletal stabili
Molecular Weight	50 kDa
Amino Acids	445 aa
Exons	4
Pathways	oxidative stress response
GeneCards	TUBB1
Human Protein Atlas	TUBB1
Middle domain (residues 240-340)	Contains binding sites for taxanes and other microtubule-binding agents. TUBB1 has specific residues here that confer sensitivity to certain drugs.
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AND, CANCER, RNA
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TUBB1 — Tubulin Beta 1

gene · 1634 words

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Pathway Diagram

graph TD
    TUBB1["TUBB1"]
    Cancer{"Cancer"}
    TUBB1 -.->|"inhibits"| Cancer
    Cardiovascular{"Cardiovascular"}
    TUBB1 -->|"expressed_in"| Cardiovascular
    CANCER(["CANCER"])
    TUBB1 -.->|"inhibits"| CANCER
    HMGCR(["HMGCR"])
    TUBB1 -->|"expressed_in"| HMGCR
    RNA(["RNA"])
    TUBB1 -->|"therapeutic_target"| RNA
    MMP3(["MMP3"])
    TUBB1 -->|"therapeutic_target"| MMP3
    CXCL8(["CXCL8"])
    CXCL8 -->|"therapeutic_target"| TUBB1
    ICAM1(["ICAM1"])
    ICAM1 -->|"therapeutic_target"| TUBB1
    style TUBB1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (12)

Target	Relation	Type	Str
Cancer	inhibits	disease	0.65
Cardiovascular	expressed_in	disease	0.65
CANCER	inhibits	gene	0.60
oxidative stress response	participates_in	pathway	0.60
HMGCR	expressed_in	gene	0.60
Rb	therapeutic_target	protein	0.60
Raf	therapeutic_target	protein	0.60
MMP3	therapeutic_target	gene	0.60
CXCL8	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
Prostate Cancer	activates	disease	0.50
cancer	activates	disease	0.50

Incoming (18)

Source	Relation	Type	Str
genes-tubb1	describes	wiki_page	1.00
genes-tubb1	documents	wiki_page	1.00
RNA	therapeutic_target	gene	0.60
GENES	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
AND	activates	gene	0.60
CXCL8	therapeutic_target	gene	0.60
MMP3	therapeutic_target	gene	0.60
ICAM1	therapeutic_target	gene	0.60
HMGCR	therapeutic_target	gene	0.60
CCL20	therapeutic_target	gene	0.60
MMP3	expressed_in	gene	0.60
ICAM1	expressed_in	gene	0.60
CXCL8	expressed_in	gene	0.60
CCL20	expressed_in	gene	0.60
ICAM1	co_expressed_with	gene	0.50
MMP3	co_expressed_with	gene	0.50
RNA	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUBB1 in their description or question text

No additional research found