ATP2B1

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP2B1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Page for ATP2B1 Gene - Plasma Membrane Calcium ATPase 1

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graph TD
    ATP2B1["ATP2B1 (PMCA1)"]
    Ca_influx["Calcium Influx"]
    Ca_cytosol["Cytosolic Ca2+"]
    Ca_pump["Ca2+-ATPase Activity"]
    Ca_extrusion["Calcium Extrusion"]
    ATP_hydrolysis["ATP Hydrolysis"]
    Ca_homeostasis["Calcium Homeostasis"]
    ER_stress["ER Stress"]
    Mitochondrial_dysfunction["Mitochondrial Dysfunction"]
    Oxidative_stress["Oxidative Stress"]
    Synaptic_dysfunction["Synaptic Dysfunction"]
    Neuronal_death["Neuronal Death"]
    Neurodegeneration["Neurodegeneration"]
    Aging["Aging"]
    AD["Alzheimer's Disease"]
    PD["Parkinson's Disease"]

    Ca_influx -->|"increases"| Ca_cytosol
    ATP2B1 -->|"encodes"| Ca_pump
    Ca_pump -->|"utilizes"| ATP_hydrolysis
    Ca_pump -->|"promotes"| Ca_extrusion
    Ca_cytosol -->|"substrate"| Ca_pump
    Ca_extrusion -->|"maintains"| Ca_homeostasis
    Ca_cytosol -->|"excess causes"| ER_stress
    Ca_cytosol -->|"overload causes"| Mitochondrial_dysfunction
    ER_stress -->|"triggers"| Oxidative_stress
    Mitochondrial_dysfunction -->|"generates"| Oxidative_stress
    Ca_cytosol -->|"disrupts"| Synaptic_dysfunction
    Oxidative_stress -->|"leads to"| Neuronal_death
    Synaptic_dysfunction -->|"contributes to"| Neuronal_death
    Neuronal_death -->|"causes"| Neurodegeneration
    Aging -->|"reduces"| ATP2B1
    Neurodegeneration -->|"manifests in"| AD
    Neurodegeneration -->|"manifests in"| PD

    classDef central fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    classDef protective fill:#1a3a2a,stroke:#81c784,stroke-width:2px,color:#fff
    classDef pathological fill:#3a1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
    classDef regulatory fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px,color:#fff
    classDef disease fill:#3a2a1a,stroke:#ffa726,stroke-width:2px,color:#fff

    class ATP2B1 central
    class Ca_pump,Ca_extrusion,Ca_homeostasis protective
    class Ca_cytosol,ER_stress,Mitochondrial_dysfunction,Oxidative_stress,Synaptic_dysfunction,Neuronal_death,Neurodegeneration pathological
    class Ca_influx,ATP_hydrolysis,Aging regulatory
    class AD,PD disease

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