gene

ATF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

0Hypotheses

0Analyses

8Outgoing

5Incoming

0Experiments

0Debates

No summary available yet.

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🧬 Gene Info

Gene Symbol	ATF1
Full Name	Activating Transcription Factor 1
Chromosome	12q13.13
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	brain (widespread), testis, adrenal gland, and various tissues
UniProt ID	P18846
NCBI Gene ID	466
Ensembl ID	ENSG00000123268
OMIM	607463
GeneCards	ATF1
Human Protein Atlas	ATF1
Associated Diseases	Neurodegeneration, depression and addiction
Interactions	AND, CREB
KG Connections	13 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ATF1 Gene (Activating Transcription Factor 1)

gene · 626 words

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Pathway Diagram

graph TD
    ATF1["ATF1"] -->|"therapeutic target"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATF1["ATF1"] -->|"therapeutic target"| Obesity["Obesity"]
    style Obesity fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATF1["ATF1"] -->|"therapeutic target"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATF1["ATF1"] -->|"therapeutic target"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATF1["ATF1"] -->|"therapeutic target"| Cardiovascular["Cardiovascular"]
    style Cardiovascular fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATF1["ATF1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    style Carcinoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ATF1["ATF1"] -->|"activates"| CREB["CREB"]
    style CREB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    YES1["YES1"] -->|"therapeutic target"| ATF1["ATF1"]
    style YES1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    AND["AND"] -->|"activates"| ATF1["ATF1"]
    style AND fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    SRC["SRC"] -->|"therapeutic target"| ATF1["ATF1"]
    style SRC fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CANCER["CANCER"] -->|"therapeutic target"| ATF1["ATF1"]
    style CANCER fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    YAP["YAP"] -->|"therapeutic target"| ATF1["ATF1"]
    style YAP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ATF1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (8)

Target	Relation	Type	Str
Tumor	therapeutic_target	disease	0.65
Obesity	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
CREB	activates	gene	0.60
KRAS	therapeutic_target	gene	0.60

Incoming (5)

Source	Relation	Type	Str
YES1	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
AND	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
YAP	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATF1 in their description or question text

No additional research found