| Gene Symbol | VPS45 |
| Full Name | Vacuolar Protein Sorting 45 Homolog |
| Chromosome | 1q21.2 |
| Function | is a critical regulator of intracellular membrane trafficking, particularly within the endosomal and secretory pathways. |
| Primary Expression | neurons and glial cells, including astrocytes and microglia |
| Amino Acids | 524 aa |
| Ensembl ID | ENSG00000136631 |
| GeneCards | VPS45 |
| Human Protein Atlas | VPS45 |
| SNARE Proteins | VPS45 binds to syntaxin proteins (particularly Syntaxin 16 and Syntaxin 6) to regulate SNARE complex assembly |
| Rab GTPases | Works with Rab5 and Rab7 in early and late endosome function |
| HOPS Complex | Collaborates with the homotypic fusion and vacuole protein sorting (HOPS) complex for late endosome-lysosome fusion |
| ESCRT Machinery | Functions in endosomal sorting complex required for transport (ESCRT) pathways |
| Amyloid Processing | VPS45 regulates trafficking of the amyloid precursor protein (APP) and β-secretase (BACE1), affecting amyloid-β production |
| Autophagy Impairment | Defective VPS45 function leads to impaired autophagic clearance of protein aggregates, including amyloid plaques and neurofibrillary tangles |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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