| Gene Symbol | VPS4 |
| Function | VPS4 (Vacuolar Protein Sorting 4 Homolog) is an AAA+ ATPase that functions in the final stages of multivesicular body (MVB) sorting and autophagy |
| Primary Expression | neuronal tissues |
| Amino Acids | 437 aa |
| UniProt ID | VPS4A |
| GeneCards | VPS4 |
| Human Protein Atlas | VPS4 |
| AAA+ ATPase domain | Hexameric ring that hydrolyzes ATP for disassembly |
| C-terminal region | Contains autoinhibitory domain |
| VPS4A | Ubiquitously expressed isoform |
| VPS4B | Predominantly expressed in neuronal tissues |
| ESCRT-III disassembly | Uses ATP hydrolysis to disassemble ESCRT-III polymers |
| MVB sorting | Essential for sorting ubiquitinated cargo into intralumenal vesicles |
| Autophagosome closure | Involved in autophagosome closure and lysosomal fusion |
| Cytokinetic abscission | Required for membrane fission during cytokinesis |
| Associated Diseases | neurodegeneration |
| Interactions | ALS, App, APP, CHMP2B, CHMP4B, CHMP6 |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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