gene

USF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

12Outgoing

4Incoming

0Experiments

0Debates

Summary

Page for USF1 — Upstream Transcription Factor 1

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🧬 Gene Info

Gene Symbol	USF1
Full Name	Upstream Stimulatory Factor 1
Aliases	Upstream Transcription Factor 1
Chromosome	1q22
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	36 kDa
Amino Acids	310 aa
Gene Type	Protein coding
UniProt ID	P22415
NCBI Gene ID	7399
Ensembl ID	ENSG00000158710
OMIM	191323
GeneCards	USF1
Human Protein Atlas	USF1
Associated Diseases	Als, Ataxia, Dystonia, Huntington, Ms, Parkinson
Interactions	USP14
KG Connections	16 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: USF1 — AlphaFold P22415 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

USF1 — Upstream Transcription Factor 1

gene · 828 words

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USF1 Protein

protein · 755 words

→

Pathway Diagram

graph TD
    USF1["USF1"]
    EndMT["EndMT"]
    USF1 -->|"promotes"| EndMT
    USP14["USP14"]
    USF1 -->|"activates"| USP14
    TREM2["TREM2"]
    USF1 -->|"upregulates"| TREM2
    OxPC["OxPC"]
    OxPC -->|"activates"| USF1
    Dystonia{"Dystonia"}
    USF1 -->|"associated_with"| Dystonia
    Huntington{"Huntington"}
    USF1 -->|"associated_with"| Huntington
    Ataxia{"Ataxia"}
    USF1 -->|"associated_with"| Ataxia
    Parkinson{"Parkinson"}
    USF1 -->|"associated_with"| Parkinson
    Senescence{"Senescence"}
    USF1 -->|"associated_with"| Senescence
    Ms{"Ms"}
    USF1 -->|"associated_with"| Ms
    Als{"Als"}
    USF1 -->|"associated_with"| Als
    HUNTINGTON["HUNTINGTON"]
    USF1 -->|"associated_with"| HUNTINGTON
    DNA["DNA"]
    USF1 -->|"associated_with"| DNA
    Mitochondrial_Function(["Mitochondrial Function"])
    USF1 -->|"associated_with"| Mitochondrial_Function
    MYC["MYC"]
    MYC -->|"associated_with"| USF1

Outgoing (12)

Target	Relation	Type	Str
EndMT	promotes	process	0.95
USP14	activates	gene	0.90
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Mitochondrial Function	associated_with	pathway	0.60
DNA	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60

Incoming (4)

Source	Relation	Type	Str
MYC	associated_with	gene	0.60
ATF2	associated_with	gene	0.60
YY1	associated_with	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning USF1 in their description or question text

No additional research found