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Which specific transcription factors mediate MAPT suppression during proteostati

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

TFEB-mediated transcriptional upregulation of lysosomal genes as a therapeutic s

Score: 0.679 · neuroscience · 2026-04-22

**Molecular Mechanism and Rationale** The transcription factor EB (TFEB) represents a master regulatory node in cellula

H1: TET-Mediated 5-Hydroxymethylcytosine Loss Drives Neuronal Transcriptomic Dri

Score: 0.670 · neurodegeneration · 2026-04-22

## Mechanistic Overview H1: TET-Mediated 5-Hydroxymethylcytosine Loss Drives Neuronal Transcriptomic Drift starts from t

ATF4-DDIT3 stress signaling indirectly represses MAPT transcription during prote

Score: 0.624 · neurodegeneration · 2026-04-25

Integrated stress response factors redirect transcription and chromatin regulation away from tau expression during acute

H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive

Score: 0.610 · neurodegeneration · 2026-04-22

## Mechanistic Overview H2: H3K9me3 Heterochromatin Collapse Enables Cryptic Transcription of Repetitive Elements starts

HSF1 reprioritizes transcription and suppresses MAPT while restoring proteostasi

Score: 0.598 · neurodegeneration · 2026-04-25

Heat-shock signaling either directly or indirectly reduces tau expression as chaperone programs dominate the stress resp

Spatial Transcriptome-Guided Precision Cell Therapy

Score: 0.578 · neurodegeneration · 2026-04-04

## Mechanistic Overview Spatial Transcriptome-Guided Precision Cell Therapy starts from the claim that modulating SOX10

Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia

Score: 0.570 · neuroinflammation · 2026-04-21

## Mechanistic Overview Direct NF-κB Transcriptional Regulation of C1q Genes in Microglia starts from the claim that mod

Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control

Score: 0.551 · neuroinflammation · 2026-04-20

## Mechanistic Overview Astrocytic SPP1 Modulation Through STAT3-Dependent Transcriptional Control starts from the claim

CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering

Score: 0.535 · neurodegeneration · 2026-04-22

## Mechanistic Overview CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent

miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription

Score: 0.520 · neurodegeneration · 2026-04-21

## Mechanistic Overview miR-143/145 Cluster Dysregulation Derepresses P2RY12 Transcription starts from the claim that mo

AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal Epigenetic Age Witho

Score: 0.520 · neurodegeneration · 2026-04-22

## Mechanistic Overview AAV-PHP.eB-Medium OSK Expression Reverses Cortical Neuronal Epigenetic Age Without Altering Glia

Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegenera

Score: 0.519 · Alzheimer disease · 2026-04-24

## Mechanistic Overview Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegeneration-Like Signat

Hippocampus ages transcriptionally faster than cerebellum, defining a regional v

Score: 0.516 · Alzheimer's disease · 2026-04-23

## Mechanistic Overview Hippocampus ages transcriptionally faster than cerebellum, defining a regional vulnerability axi

Transcriptome-wide competition determines functional selectivity after direct bi

Score: 0.509 · molecular neurobiology · 2026-04-25

lncRNA-0021 may not be uniquely specific at the physical binding level; instead, its apparent selectivity for mmu-miR-63

PKM2 nuclear translocation bridges metabolism and inflammatory transcription in

Score: 0.506 · neuroinflammation · 2026-04-21

## Mechanistic Overview PKM2 nuclear translocation bridges metabolism and inflammatory transcription in primed microglia