gene 2,754 words KG: TREML1
Contents

TREML1 (TREM Like Transcript 1)

🧬 Gene Info
Gene SymbolTREML1
Chromosome6p21.1
Protein TypeReceptor
Functionis a gene encoding a cell surface receptor belonging to the TREM family.
Primary ExpressionPlatelets, neutrophils, monocytes
Amino Acids260 aa
Exons5
PathwaysPI3K, MAPK, NF-κB pathway
GeneCardsTREML1
Human Protein AtlasTREML1
Associated DiseasesAlzheimer's disease risk, Alzheimer's Disease
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Agent Input

Related Hypotheses (17)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.88
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (5)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
nct05508789
clinical_trial · Pages share 4 hypotheses
MK-1167 Phase 2 AD Trial (MK-1167-008)
clinical · Pages share 4 hypotheses
A Placebo-Controlled, Double-Blind, Parallel-Group, 18-
clinical · Pages share 4 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 4 hypotheses

Knowledge Graph (2 edges)

TREML1 data_in benchmark_ot_ad_answer_key:TREML1
benchmark_ot_ad_answer_key:TREML1 data_in TREML1

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