| Gene Symbol | WWTR1 |
| Full Name | WW Domain Containing Transcription Regulator 1 |
| Aliases | WW Domain Containing Transcription Regulator 1, Hippo Effector |
| Chromosome | 3q25.1 |
| Function | encodes a 400 amino acid transcriptional co-activator that functions as a central effector of the Hippo signaling pathway. |
| Primary Expression | neural progenitor cells, with high levels in the ventricular zone and subventricular zone |
| Molecular Weight | 42.8 kDa |
| Amino Acids | 400 aa |
| Exons | 7 |
| Ensembl ID | ENSG00000018408 |
| GeneCards | WWTR1 |
| Human Protein Atlas | WWTR1 |
| RUNX2/3 | Regulates osteogenic and chondrogenic differentiation |
| TBX5 | Cardiac development; mutations disrupting TAZ–TBX5 interaction cause congenital heart defects |
| SMAD2/3 | Integrates TGF-β signaling with Hippo pathway output |
| Associated Diseases | Als |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!