concept

TUMOR PROGRESSION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TUMOR PROGRESSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

0Outgoing

44Incoming

0Experiments

0Debates

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💡 Concept Info

Name	TUMOR PROGRESSION
Key Genes/Proteins	MCT1

Pathway Diagram

graph TD
    TUMOR_PROGRESSION["TUMOR PROGRESSION"]
    Glutathione["Glutathione"] -->|"promotes"| TUMOR_PROGRESSION
    NPM1["NPM1"] -->|"promotes"| TUMOR_PROGRESSION
    CLDN18_2["CLDN18.2"] -->|"contributes to"| TUMOR_PROGRESSION
    Mechanotransducers["Mechanotransducers"] -->|"contributes to"| TUMOR_PROGRESSION
    AIMP2_DX2["AIMP2-DX2"] -->|"contributes to"| TUMOR_PROGRESSION
    SERPINE1["SERPINE1"] -->|"promotes"| TUMOR_PROGRESSION
    Genetic_Drivers["Genetic Drivers"] -->|"contributes to"| TUMOR_PROGRESSION
    LOX["LOX"] -->|"correlates_with"| TUMOR_PROGRESSION

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (44)

Source	Relation	Type	Str
Glutathione	promotes	compound	0.95
Inflammation	modulates	process	0.95
EGFR-AKT-TSPAN8-STAT3 Pathway	associated_with	pathway	0.95
PIEZO1	involved_in	gene	0.95
NPM1	associated_with	protein	0.95
CLDN18.2	contributes_to	protein	0.92
Autophagy	associated_with	process	0.90
LOXL1	correlates_with	gene	0.90
Ecm Stiffness	regulates	pathway	0.90
Mechanotransducers	contributes_to	protein	0.90
Genetic Drivers	promotes	biomarker	0.90
LOX	promotes	gene	0.90
Genetic Drivers	contributes_to	biomarker	0.90
PI3K/Akt/mTOR	associated_with	pathway	0.90
LOX	correlates_with	gene	0.90
EGFR-AKT-TSPAN8-STAT3 Axis	associated_with	pathway	0.90
Tumor Neo-innervation	associated_with	process	0.90
SERPINE1	promotes	protein	0.90
HDAC11	involved_in	gene	0.90
HDAC7	involved_in	gene	0.90
AIMP2-DX2	contributes_to	protein	0.90
HDAC3	involved_in	gene	0.90
HDAC5	involved_in	gene	0.90
Circadian Rhythm Disruption	contributes_to	phenotype	0.88
Mechanotransducers	regulates	mechanism	0.85
Tumor-Associated Macrophages	promotes	cell_type	0.85
SREBF1	drives	gene	0.85
CAF	associated_with	cell_type	0.85
circadian rhythm disruption	promotes	phenotype	0.85
HDAC5	drives	gene	0.85
HDAC7	contributes_to	gene	0.80
HSP70	associated_with	protein	0.80
VEGF	involved_in	protein	0.80
LOXL1	promotes	gene	0.80
LOXL2	promotes	gene	0.80
LOXL3	promotes	gene	0.80
LOXL4	promotes	gene	0.80
Metabolic Pathway Disruption	contributes_to	pathway	0.75
RAS/MAPK pathway	activates	pathway	0.70
MMP9	activates	protein	0.70
Circadian Clock Disruption	contributes_to	phenotype	0.70
circadian clock	involved_in	pathway	0.65
Clock Disruption	contributes_to	phenotype	0.60
MCT1	contributes_to	protein	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TUMOR PROGRESSION in their description or question text

No additional research found