Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TGF-BETA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | TGF |
| Function | TGF-β Receptor 1 (TGFBR1) is a transmembrane serine/threonine kinase that serves as the primary type I receptor for transforming growth factor-beta ligands in the nervous system. |
| Molecular Weight | ~56 kDa |
| Amino Acids | 503 amino acids |
| Pathways | unfolded protein response, TGF-beta signaling, neurotrophin signaling, NF-kB signaling, oxidative stress response |
| GeneCards | TGF |
| Human Protein Atlas | TGF |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, cancer, cardiovascular disease, glioblastoma |
| Known Drugs/Compounds | curcumin, rapamycin |
| Interactions | ADAMTS4, AKT, AMPK, ANGPT1, APP, AQP1 |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
graph TD
A["Gene expression"] --> B["TGF BETA1"]
B --> C["Protein folding and
quality control"]
B --> D["Cellular signaling"]
C --> E["Proteostasis"]
D --> F["Neurotoxicity"]
E --> G["Disease outcome"]
F --> G
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class B protein
class G disease| Target | Relation | Type | Str |
|---|---|---|---|
| Pulmonary Arterial Hypertension | associated_with | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning TGF-BETA1 in their description or question text
No additional research found