| Gene Symbol | TGF |
| Full Name | beta1 Protein |
| Function | TGF-β Receptor 1 (TGFBR1) is a transmembrane serine/threonine kinase that serves as the primary type I receptor for transforming growth factor-beta ligands in the nervous system. |
| Subcellular Localization | </strong> Secreted (latent complex stored in ECM)</div> |
| Molecular Weight | ~56 kDa |
| Amino Acids | 503 amino acids |
| Pathways | unfolded protein response, TGF-beta signaling, neurotrophin signaling, NF-kB signaling, oxidative stress response |
| GeneCards | TGF |
| Human Protein Atlas | TGF |
| Multiple Sclerosis | TGF-beta1 deficiency worsens disease; therapeutic potential for boosting signaling. |
| Stroke | TGF-beta1 is upregulated after ischemia and contributes to repair. |
| TGF-beta1 Agonists | Being explored for neuroprotection |
| TGF-beta1 Antagonists | Used in some cancer therapies; unclear benefit for neurodegeneration |
| Smad-dependent signaling modulators | Downstream pathway targets |
| Associated Diseases | ALS, Alzheimer, Alzheimer's disease, cancer, cardiovascular disease, glioblastoma |
| Known Drugs/Compounds | curcumin, rapamycin |
| Interactions | ADAMTS4, AKT, AMPK, ANGPT1, APP, AQP1 |
| KG Connections | 251 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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