concept

SORAFENIB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORAFENIB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

25Outgoing

33Incoming

0Experiments

0Debates

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💡 Concept Info

Name	SORAFENIB
Key Genes/Proteins	ACSL4, BECN1, BRAF, GPX4, MEK, NRF2
Related Diseases	CANCER, FIBROSIS, GLUTAMATE, HEPATOCELLULAR CARCINOMA

Pathway Diagram

graph TD
    SORAFENIB["SORAFENIB"]
    SORAFENIB -->|"activates"| ferroptosis["ferroptosis"]
    SORAFENIB -->|"inhibits"| SYSTEM_XC_["SYSTEM XC-"]
    SORAFENIB -->|"treats"| Liver_Fibrosis["Liver Fibrosis"]
    SORAFENIB -->|"inhibits"| Extracellular_Matrix_Accumulat["Extracellular Matrix Accumulation"]
    SORAFENIB -->|"treats"| liver_fibrosis["liver_fibrosis"]
    SORAFENIB -->|"upregulates"| IL12A["IL12A"]
    SORAFENIB -->|"regulates"| HIF1A["HIF1A"]
    SORAFENIB -->|"regulates"| STEM_CELLS["STEM CELLS"]
    GPAT3["GPAT3"] -->|"targets"| SORAFENIB
    SLC7A11["SLC7A11"] -->|"regulates"| SORAFENIB
    NRF2["NRF2"] -->|"regulates"| SORAFENIB
    GPX4["GPX4"] -->|"regulates"| SORAFENIB
    FERROPTOSIS["FERROPTOSIS"] -->|"regulates"| SORAFENIB
    FIBROSIS["FIBROSIS"] -->|"regulates"| SORAFENIB
    ACSL4["ACSL4"] -->|"regulates"| SORAFENIB
    BECN1["BECN1"] -->|"activates"| SORAFENIB

Outgoing (25)

Target	Relation	Type	Str
Hepatic Stellate Cell Ferroptosis	associated_with	process	0.95
Liver Fibrosis	treats	disease	0.90
ferroptosis	activates	pathway	0.90
SYSTEM XC-	inhibits	protein	0.90
Extracellular Matrix Accumulation	inhibits	process	0.85
liver_fibrosis	treats	disease	0.72
IL12A	upregulates	gene	0.70
FIBROSIS	treats	disease	0.65
HIF1A	regulates	protein	0.64
MELATONIN	associated_with	drug	0.45
FIBROSIS	associated_with	disease	0.45
ACSL4	associated_with	gene	0.45
BECN1	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
BRAF	associated_with	gene	0.45
GLUTAMATE	associated_with	phenotype	0.45
TNF	associated_with	gene	0.45
STEM CELLS	associated_with	cell_type	0.45
TRAMETINIB	associated_with	drug	0.45
VEMURAFENIB	associated_with	drug	0.45
SLC7A11	associated_with	gene	0.45
NRF2	associated_with	gene	0.45
GPX4	associated_with	gene	0.45
STEM CELLS	regulates	cell_type	0.35
TNF	inhibits	gene	0.35

Incoming (33)

Source	Relation	Type	Str
GPAT3	targets	gene	0.80
STEM CELLS	associated_with	cell_type	0.45
VEMURAFENIB	associated_with	drug	0.45
DABRAFENIB	associated_with	drug	0.45
TRAMETINIB	associated_with	drug	0.45
N-ACETYLCYSTEINE	associated_with	drug	0.45
GPX4	associated_with	gene	0.45
NRF2	associated_with	gene	0.45
SLC7A11	associated_with	gene	0.45
ACSL4	associated_with	gene	0.45
FIBROSIS	associated_with	disease	0.45
MELATONIN	associated_with	drug	0.45
BECN1	associated_with	gene	0.45
BRAF	associated_with	gene	0.45
GLUTAMATE	associated_with	phenotype	0.45
BRAF	inhibits	gene	0.35
RAF	inhibits	gene	0.35
MEK	inhibits	gene	0.35
SLC7A11	regulates	gene	0.35
NRF2	regulates	gene	0.35
GPX4	regulates	gene	0.35
FERROPTOSIS	regulates	process	0.35
FIBROSIS	regulates	disease	0.35
ACSL4	regulates	gene	0.35
BECN1	activates	gene	0.35
FERROPTOSIS	inhibits	process	0.35
FIBROSIS	inhibits	disease	0.35
SLC7A11	inhibits	gene	0.35
FIBROSIS	activates	disease	0.35
FERROPTOSIS	associated_with	process	0.35
SLC7A11	activates	gene	0.35
HEPATOCELLULAR CARCINOMA	activates	disease	0.35
N-ACETYLCYSTEINE	inhibits	drug	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SORAFENIB in their description or question text

No additional research found