| Gene Symbol | SPG11 |
| Aliases | Page for SPG11 Gene |
| Chromosome | 10p14 |
| Function | is a large cytoplasmic protein encoded by the SPG11 gene located on chromosome 15q21. |
| Primary Expression | Predominantly neuronal |
| Molecular Weight | 250 kDa |
| Amino Acids | 163 aa |
| Exons | 40 |
| UniProt ID | Q96MC7 |
| NCBI Gene ID | 80208 |
| GeneCards | SPG11 |
| Human Protein Atlas | SPG11 |
| Endolysosomal trafficking | SPG11 regulates the movement and function of endosomes and lysosomes along microtubules, essential for neuronal homeostasis[@renvoise2022] |
| Autophagy | SPG11 is required for proper autophagosome formation and fusion with lysosomes, critical for clearing misfolded proteins and damaged organelles[@chang2023] |
| Lysosomal tubular network | SPG11 maintains the tubular lysosomal network important for cellular waste removal and nutrient recycling[@liu2021] |
| Associated Diseases | Inflammation, neurodegeneration, Neuroinflammation |
| Interactions | MICROGLIA, NEURODEGENERATION |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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