gene

SPG15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPG15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

1Outgoing

3Incoming

0Experiments

0Debates

Summary

SPG15 gene page for hereditary spastic paraplegia

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🧬 Gene Info

Gene Symbol	SPG15
Full Name	Spastic Paraplegia 15
Chromosome	14q24.3.
Protein Type	Gene
Function	is a hereditary neurological disorder classified as a complex form of hereditary spastic paraplegia (HSP) characterized by progressive lower limb spasticity and weakness.
Molecular Weight	209 kDa
Amino Acids	897 aa
Exons	47
GeneCards	SPG15
Human Protein Atlas	SPG15
Zinc Finger Domains	Multiple C2H2-type zinc finger motifs are present throughout the protein, suggesting roles in DNA binding or protein-protein interactions.
Proline-Rich Region	The central region contains proline-rich sequences that may serve as interaction sites for SH3 domain-containing proteins involved in signaling pathways.
Associated Diseases	neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SPG15 Gene - Spastic Paraplegia 15

gene · 2701 words

→

SPG15 Protein - ZFYVE26

protein · 890 words

→

Pathway Diagram

flowchart TD
    SPG15(["SPG15"])
    Autophagy["Autophagy"]
    LYSOSOME(["LYSOSOME"])
    AUTOPHAGY(["AUTOPHAGY"])
    SPG11(["SPG11"])
    neurodegeneration["neurodegeneration"]

    SPG15 -->|"implicated in"| Autophagy
    LYSOSOME -->|"implicated in"| SPG15
    AUTOPHAGY -->|"implicated in"| SPG15
    SPG11 -->|"associated with"| SPG15
    SPG15 -->|"implicated in"| neurodegeneration

    style SPG15 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (1)

Target	Relation	Type	Str
Autophagy	implicated_in	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
LYSOSOME	implicated_in	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
SPG11	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPG15 in their description or question text

No additional research found