protein 1,084 words KG: SPG11
Contents

SPG11 Cytoskeletal Protein

🔬 Protein Info
Gene SymbolSPG11
AliasesPage for SPG11 Gene
Chromosome10p14
Functionis a large cytoplasmic protein encoded by the SPG11 gene located on chromosome 15q21.
Primary ExpressionPredominantly neuronal
Molecular Weight250 kDa
Amino Acids163 aa
Exons40
UniProt IDQ96MC7
NCBI Gene ID80208
GeneCardsSPG11
Human Protein AtlasSPG11
Associated DiseasesInflammation, neurodegeneration, Neuroinflammation
InteractionsMICROGLIA, NEURODEGENERATION
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.85
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
R-Loop Resolution Enhancement Therapy
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.67

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (6)

Neuroinflammation PET Imaging in CBS/PSP
diagnostic · KG edge: associated_with
Neurodegeneration
disease · KG edge: inhibits
Microglia in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: implicated_in
SPG15 Gene - Spastic Paraplegia 15
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SPG11 associated_with SPG15
ALS2 associated_with SPG11
ANG associated_with SPG11
DAO associated_with SPG11
DCTN1 associated_with SPG11
FIG4 associated_with SPG11
FUS associated_with SPG11
NEFH associated_with SPG11
OPTN associated_with SPG11
SETX associated_with SPG11

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