Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PIEZO1 AND KCNK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PIEZO1 AND KCNK2 |
graph TD
PIEZO1_AND_KCNK2[PIEZO1 AND KCNK2]
PIEZO1_AND_KCNK2 -->|debate_co_mention| PTGS2[PTGS2]
PIEZO1_AND_KCNK2 -->|debate_co_mention| SOAT1[SOAT1]
PIEZO1_AND_KCNK2 -->|debate_co_mention| TET2[TET2]
PIEZO1_AND_KCNK2 -->|debate_co_mention| RNA[RNA]
PIEZO1_AND_KCNK2 -->|implicated in| neurodegeneration[neurodegeneration]
PIEZO1_AND_KCNK2 -->|data_in| benchmark_ot_ad_answer_key_PIE[benchmark_ot_ad_answer_key:PIEZO1 AND KCNK2]
C1Q[C1Q] -->|activates| PIEZO1_AND_KCNK2
phagocytosis[phagocytosis] -->|activates| PIEZO1_AND_KCNK2
h_db6aa4b1[h-db6aa4b1] -->|targets| PIEZO1_AND_KCNK2
neuroinflammation[neuroinflammation] -->|debate_co_mention| PIEZO1_AND_KCNK2
P2RX7[P2RX7] -->|debate_co_mention| PIEZO1_AND_KCNK2
P2RY1[P2RY1] -->|debate_co_mention| PIEZO1_AND_KCNK2
PIEZO1[PIEZO1] -->|debate_co_mention| PIEZO1_AND_KCNK2
MIRO1[MIRO1] -->|debate_co_mention| PIEZO1_AND_KCNK2
P2RY1_and_P2RX7[P2RY1 and P2RX7] -->|debate_co_mention| PIEZO1_AND_KCNK2
BMAL1[BMAL1] -->|co_associated_with| PIEZO1_AND_KCNK2| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PIEZO1 AND KCNK2 | data_in | dataset_row | 0.00 |
| PTGS2 | debate_co_mention | gene | 0.45 |
| SOAT1 | debate_co_mention | gene | 0.45 |
| TET2 | debate_co_mention | gene | 0.45 |
| RNA | debate_co_mention | gene | 0.45 |
| TET2 | co_associated_with | gene | 0.40 |
| neurodegeneration | associated_with | disease | 0.40 |
| neurodegeneration | implicated_in | disease | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PIEZO1 AND KCNK2 | data_in | dataset_row | 0.00 |
| C1Q | activates | gene | 0.55 |
| phagocytosis | activates | process | 0.55 |
| h-db6aa4b1 | targets | hypothesis | 0.50 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| P2RX7 | debate_co_mention | gene | 0.45 |
| P2RY1 | debate_co_mention | gene | 0.45 |
| PIEZO1 | debate_co_mention | gene | 0.45 |
| MIRO1 | debate_co_mention | gene | 0.45 |
| P2RY1 and P2RX7 | debate_co_mention | gene | 0.45 |
| BMAL1 | co_associated_with | gene | 0.40 |
| DGAT1 and SOAT1 | co_associated_with | gene | 0.40 |
| HK2 | co_associated_with | gene | 0.40 |
| MIRO1 | co_associated_with | gene | 0.40 |
| P2RY1 and P2RX7 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mechanosensitive Ion Channel Reprogramming | 0.700 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| TREK-1 regulation of conventional outflow facility in mouse eyes | validation | ocular hypertension | 0.900 | 0.00 | mouse eyes | proposed | N/A |
| DEX effects on TREK-1 currents in human primary TM cells | exploratory | corticosteroid-induced ocular | 0.900 | 0.00 | primary human trabecular meshw | proposed | N/A |
| TREK-1 effects on IOP in DEX-induced mouse OHT model | validation | dexamethasone-induced ocular h | 0.900 | 0.00 | mouse eyes | proposed | N/A |
| DEX effects on K2P channel transcriptome in mouse TM cells | exploratory | corticosteroid-induced ocular | 0.900 | 0.00 | mouse trabecular meshwork cell | proposed | N/A |
| TREK-1 effects on spontaneous OHT in rats using telemetry | validation | spontaneous ocular hypertensio | 0.800 | 0.00 | rat eyes | proposed | N/A |
| TREK-1 localization in trabecular meshwork by immunohistochemistry | exploratory | ocular hypertension | 0.800 | 0.00 | trabecular meshwork tissue | proposed | N/A |
| Proposed experiment from debate on Perivascular spaces and glymphatic | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $240,000 |
| Endocannabinoid System Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $200,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Identification of mechanosensitive ion channel-related molecular subtypes and ke [PMID:40950697] | Zhang L, Wang L, Wang M, Peng K, Chen H, | Transl Cancer Res | 2025 | 1 |
| Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regulate Conventional Outf [PMID:41268978] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | Invest Ophthalmol Vis Sci | 2025 | 1 |
| Inflammation alters the expression and activity of the mechanosensitive ion chan [PMID:39789885] | Ren J, Zhan C, Lin Y | Eur J Orthod | 2024 | 1 |
| Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007] | Zong B, Yu F, Zhang X, Pang Y, Zhao W, S | Ageing Res Rev | 2023 | 1 |
| Piezo-type mechanosensitive ion channel component 1: a mechano-bioenergetic tran [PMID:41437911] | ["Zhang Y", "Gao C", "Li Y", "Fu Q", "Li | Annals of medicine | 2026 | 0 |
| Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic [PMID:40653265] | ["Li R", "Xia J", "Shi C", "Zhang K", "Q | Journal of advanced research | 2026 | 0 |
| Piezo1: structural pharmacology and mechanotransduction mechanisms. [PMID:40750459] | ["Wang J", "Jing F", "Zhao Y", "You Z", | Trends in pharmacological scie | 2025 | 0 |
| Emerging roles of mechanically activated ion channels in autoimmune disease. [PMID:40194731] | ["Zeng Z", "Chen E", "Xue J"] | Autoimmunity reviews | 2025 | 0 |
| Local soft niches in mechanically heterogeneous primary tumors promote brain met [PMID:40009679] | ["Tang K", "Zheng Y", "Hu G", "Xin Y", " | Science advances | 2025 | 0 |
| Amyloid beta Aβ [PMID:39722451] | ["Lim X", "Willemse L", "Harraz O"] | Biophysical journal | 2025 | 0 |
| Mechanosensitive channel Piezo1 in calcium dynamics: structure, function, and em [PMID:41195420] | Liu Y, Xu YQ, Long YY, Xiao H, Ma YY, Li | Frontiers in molecular bioscie | 2025 | 0 |
| PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy o [PMID:41051683] | Gupta T, Singh TG, Singh R | Molecular biology reports | 2025 | 0 |
| Mechanosensation of the heart and gut elicits hypometabolism and vigilance in mi [PMID:39824919] | ["Scott K", "Tan Y", "Johnson D", "Elsaa | Nature metabolism | 2025 | 0 |
| Corticosteroids elevate intraocular pressure through suppression of TREK-1 signa [PMID:40894745] | Redmon SN, Yarishkin O, Rudzitis CN, Lak | bioRxiv : the preprint server | 2025 | 0 |
| Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow [PMID:39375369] | ["Lim X", "Abd-Alhaseeb M", "Ippolito M" | Nature communications | 2024 | 0 |
| Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid h [PMID:39436995] | ["Zhang J", "Zhao Y", "Wu S", "Han M", " | Science signaling | 2024 | 0 |
| Biophysical and mechanobiological considerations for T-cell-based immunotherapy. [PMID:37172572] | ["Zhuang C", "Gould J", "Enninful A", "S | Trends in pharmacological scie | 2023 | 0 |
| Mechanosensitive ion channel Piezo1 mediates mechanical ventilation-exacerbated [PMID:36526145] | ["Fang X", "Li M", "Wang Y", "Zhang P", | Journal of advanced research | 2023 | 0 |
| Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular [PMID:37587100] | ["Freitas-Andrade M", "Comin C", "Van Dy | Nature communications | 2023 | 0 |
| Focused ultrasound excites cortical neurons via mechanosensitive calcium accumul [PMID:35078979] | ["Yoo S", "Mittelstein D", "Hurt R", "La | Nature communications | 2022 | 0 |
Multi-agent debates referencing this entity