concept

P2RY1 AND P2RX7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P2RY1 AND P2RX7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

1Hypotheses

1Analyses

9Outgoing

10Incoming

4Experiments

1Debates

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💡 Concept Info

Name	P2RY1 AND P2RX7

Pathway Diagram

graph TD
    P2RY1_AND_P2RX7[P2RY1 AND P2RX7]
    P2RY1_AND_P2RX7 -->|debate_co_mention| PIEZO1[PIEZO1]
    P2RY1_AND_P2RX7 -->|debate_co_mention| PIEZO1_and_KCNK2[PIEZO1 and KCNK2]
    P2RY1_AND_P2RX7 -->|debate_co_mention| SOAT1[SOAT1]
    P2RY1_AND_P2RX7 -->|debate_co_mention| TET2[TET2]
    P2RY1_AND_P2RX7 -->|implicated in| neurodegeneration[neurodegeneration]
    P2RY1_AND_P2RX7 -->|data_in| benchmark_ot_ad_answer_key_P2R[benchmark_ot_ad_answer_key:P2RY1 AND P2RX7]
    h_0758b337[h-0758b337] -->|targets| P2RY1_AND_P2RX7
    DGAT1_and_SOAT1[DGAT1 and SOAT1] -->|debate_co_mention| P2RY1_AND_P2RX7
    HK2[HK2] -->|debate_co_mention| P2RY1_AND_P2RX7
    MIRO1[MIRO1] -->|debate_co_mention| P2RY1_AND_P2RX7
    P2RY1[P2RY1] -->|debate_co_mention| P2RY1_AND_P2RX7
    BMAL1[BMAL1] -->|co_associated_with| P2RY1_AND_P2RX7
    benchmark_ot_ad_answer_key_P2R -->|data_in| P2RY1_AND_P2RX7

Outgoing (9)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P2RY1 AND P2RX7	data_in	dataset_row	0.00
PIEZO1	debate_co_mention	gene	0.45
PIEZO1 and KCNK2	debate_co_mention	gene	0.45
SOAT1	debate_co_mention	gene	0.45
TET2	debate_co_mention	gene	0.45
neurodegeneration	associated_with	disease	0.40
neurodegeneration	implicated_in	disease	0.40
TET2	co_associated_with	gene	0.40
PIEZO1 and KCNK2	co_associated_with	gene	0.40

Incoming (10)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:P2RY1 AND P2RX7	data_in	dataset_row	0.00
h-0758b337	targets	hypothesis	0.50
HK2	debate_co_mention	gene	0.45
MIRO1	debate_co_mention	gene	0.45
P2RY1	debate_co_mention	gene	0.45
DGAT1 and SOAT1	debate_co_mention	gene	0.45
DGAT1 and SOAT1	co_associated_with	gene	0.40
MIRO1	co_associated_with	gene	0.40
HK2	co_associated_with	gene	0.40
BMAL1	co_associated_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Purinergic Signaling Polarization Control	0.713	neurodegeneration	Astrocyte reactivity subtypes in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Astrocyte reactivity subtypes in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741

Experiments (4)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
s:** - GPR32 knockout in microglia should worsen neuroinflammation if	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$240,000
Endocannabinoid System Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Purinergic Signaling Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Purinergic signaling elements are correlated with coagulation players in periphe [PMID:35091759]	Schultz IC, Bertoni APS, Wink MR	J Mol Med (Berl)	2022	1
Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma? [PMID:35386996]	Thompson RJ, Sayers I, Kuokkanen K, Hall	Front Allergy	2021	1
Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in m [PMID:25719930]	Todd JN, Poon W, Lyssenko V, Groop L, Ni	J Clin Endocrinol Metab	2015	1
CSF ATP levels correlate with Alzheimer's disease severity and predict progressi [PMID:synthetic_4]	Unknown	JAMA Neurol	2024	0
Astrocyte phenotype switching controlled by purinergic receptor balance regulate [PMID:synthetic_1]	Unknown	Nature Neuroscience	2023	0
P2Y1 agonist enhances astrocyte-mediated neuroprotection via BDNF upregulation [PMID:synthetic_3]	Unknown	Glia	2023	0
Astrocyte phenotype heterogeneity may not fit simple A1/A2 binary classification [PMID:synthetic_8]	Unknown	Cell	2023	0
P2X7 antagonists failed to show efficacy in depression trials despite target eng [PMID:synthetic_6]	Unknown	Mol Psychiatry	2022	0
P2X7 antagonist reduces amyloid pathology and preserves cognition in APP/PS1 mic [PMID:synthetic_2]	Unknown	Neurobiol Dis	2022	0
JNJ-47965567 P2X7 antagonist shows CNS penetration and safety in Phase 2 trial [PMID:synthetic_5]	Unknown	Lancet Psychiatry	2021	0
P2Y1 agonists cause platelet activation and thrombotic risk in cardiovascular mo [PMID:synthetic_7]	Unknown	Thromb Haemost	2020	0
Functional coordination and HuR-mediated regulation of mRNA stability during T c [PMID:26490963]	["Blackinton J", "Keene J"]	Nucleic acids research	2016	0
Characterization of a novel function-blocking antibody targeted against the plat [PMID:25593131]	["Karim Z", "Vemana H", "Alshbool F", "L	Arteriosclerosis, thrombosis,	2015	0
Dysregulation of leukocyte gene expression in women with medication-refractory d [PMID:24143878]	Iacob E, Light KC, Tadler SC, Weeks HR,	BMC psychiatry	2013	0
Evidence of HPV subtypes linked with cervical cancer in Nepal. [PMID:28615609]	["Bhusal C", "Manandhar S", "Singh M", "	WHO South-East Asia journal of	2012	0
Purinergic receptors are part of a functional signaling system for proliferation [PMID:12787128]	Greig AV, Linge C, Terenghi G, McGrouthe	The Journal of investigative d	2003	0

Debates (1)

Multi-agent debates referencing this entity

Astrocyte reactivity subtypes in neurodegeneration

closed · Rounds: 4 · Score: 0.95 · 2026-04-10