protein

NTRK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTRK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

14Outgoing

13Incoming

0Experiments

0Debates

Summary

NTRK1 encodes TrkA, a receptor tyrosine kinase for nerve growth factor (NGF) that mediates neuronal survival, differentiation, and synaptic plasticity. A key therapeutic target in Alzheimer's and Parkinson's disease with both agonist and antagonist strategies under investigation.

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🔬 Protein Info

Gene Symbol	NTRK1
Function	Trka (Tropomyosin Receptor Kinase A) (Ntrk1) plays an important role in the study of neurodegenerative diseases.
Molecular Weight	87 kDa
Amino Acids	796 aa
GeneCards	NTRK1
Human Protein Atlas	NTRK1
Activation	Autophosphorylation of TrkA creates docking sites for PI3K adaptor proteins (e.g., Shc, IRS-1)
PI3K activation	Generates phosphatidylinositol (3,4,5)-trisphosphate (PIP3)
Akt activation	PIP3 recruits Akt to the membrane where it is phosphorylated and activated
Survival effects	Akt phosphorylates and inhibits pro-apoptotic proteins (Bad, caspase-9)
Metabolic regulation	Akt promotes glucose metabolism and protein synthesis
Neuronal differentiation	Promotes neurite outgrowth and dendritic arborization
Synaptic plasticity	Modifies synaptic strength and structure
Gene expression	Activates transcription factors (e.g., CREB) that promote neuronal survival
Cell cycle	ERK1/2 activation can support neuronal survival under certain conditions
Associated Diseases	disease, Glioma
Interactions	AKT, CCT5, PDGFRA, RAB7, SPTLC1
KG Connections	27 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NTRK1["NTRK1"]
    BDNF["BDNF"]
    BDNF -->|"activates"| NTRK1
    LMNA["LMNA"]
    NTRK1 -->|"regulates"| LMNA
    PRDX1["PRDX1"]
    NTRK1 -->|"regulates"| PRDX1
    RNA["RNA"]
    NTRK1 -->|"regulates"| RNA
    SQSTM1["SQSTM1"]
    NTRK1 -->|"regulates"| SQSTM1
    TPM3["TPM3"]
    NTRK1 -->|"regulates"| TPM3
    NPM1["NPM1"]
    NTRK1 -->|"regulates"| NPM1
    PRDX1["PRDX1"]
    NTRK1 -->|"associated with"| PRDX1
    Genes["Genes"]
    NTRK1 -->|"causes"| Genes
    Glioma["Glioma"]
    NTRK1 -->|"causes"| Glioma
    Proteins["Proteins"]
    NTRK1 -->|"causes"| Proteins
    Genes["Genes"]
    NTRK1 -->|"interacts with"| Genes
    disease["disease"]
    NTRK1 -->|"interacts with"| disease
    disease["disease"]
    NTRK1 -->|"causes"| disease
    Neuropathy["Neuropathy"]
    NTRK1 -->|"interacts with"| Neuropathy
    Pain["Pain"]
    NTRK1 -->|"interacts with"| Pain
    arhgef2["arhgef2"]
    arhgef2 -->|"associated with"| NTRK1
    LMNA["LMNA"]
    LMNA -->|"associated with"| NTRK1
    NPM1["NPM1"]
    NPM1 -->|"associated with"| NTRK1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| NTRK1
    TPM3["TPM3"]
    TPM3 -->|"associated with"| NTRK1
    PDGFRA["PDGFRA"]
    PDGFRA -->|"causes"| NTRK1
    PDGFRA["PDGFRA"]
    PDGFRA -->|"activates"| NTRK1
    CCT5["CCT5"]
    CCT5 -->|"interacts with"| NTRK1
    SPTLC1["SPTLC1"]
    SPTLC1 -->|"interacts with"| NTRK1
    RAB7["RAB7"]
    RAB7 -->|"interacts with"| NTRK1
    SPTLC1["SPTLC1"]
    SPTLC1 -->|"causes"| NTRK1
    RAB7["RAB7"]
    RAB7 -->|"causes"| NTRK1

Outgoing (14)

Target	Relation	Type	Str
AKT	activates	gene	0.65
disease	interacts_with	disease	0.50
disease	causes	disease	0.50
Neuropathy	interacts_with	disease	0.50
Pain	interacts_with	disease	0.50
Glioma	causes	disease	0.50
Proteins	causes	protein	0.50
PRDX1	associated_with	protein	0.50
LMNA	regulates	gene	0.50
PRDX1	regulates	protein	0.50
RNA	regulates	gene	0.50
SQSTM1	regulates	gene	0.50
TPM3	regulates	gene	0.50
NPM1	regulates	gene	0.50

Incoming (13)

Source	Relation	Type	Str
Copper	downregulates	compound	0.90
CCT5	interacts_with	gene	0.50
SPTLC1	interacts_with	gene	0.50
RAB7	interacts_with	gene	0.50
SPTLC1	causes	gene	0.50
RAB7	causes	gene	0.50
PDGFRA	causes	gene	0.50
PDGFRA	activates	gene	0.50
arhgef2	associated_with	gene	0.50
LMNA	associated_with	gene	0.50
NPM1	associated_with	gene	0.50
SQSTM1	associated_with	gene	0.50
TPM3	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NTRK1 in their description or question text

No additional research found