gene

arhgef2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arhgef2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

43Connections

0Hypotheses

0Analyses

35Outgoing

8Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ARHGEF2
Full Name	Rho Guanine Nucleotide Exchange Factor 2
Chromosome	1q22
Function	ARHGEF2 encodes a Rho GEF that activates Rho GTPases, primarily RhoA, but also Rac1 and Cdc42.
Molecular Weight	220 kDa
Amino Acids	736 aa
Exons	33
UniProt ID	Q9Y5S5
NCBI Gene ID	9199
Ensembl ID	ENSG00000116584
OMIM	607560
GeneCards	ARHGEF2
Human Protein Atlas	ARHGEF2
ROCK (Rho-associated kinase)	Phosphorylates myosin light chain (MLC), enhancing contractility
Dendritic spine morphology	High ROCK activity promotes spine shrinkage/retraction
Associated Diseases	Intellectual disability, Midbrain-hindbrain malformation
Interactions	AMPK, CaMKK2, Fus, IRF2BP2, LMNA, NPM1
KG Connections	37 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: arhgef2 — AlphaFold Q9Y5S5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ARHGEF2 Gene

gene · 746 words

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Pathway Diagram

graph TD
    ARHGEF2["ARHGEF2"]
    ARHGEF2 -->|"activates"| RhoA["RhoA"]
    ARHGEF2 -->|"causes"| Intellectual_disability["Intellectual disability"]
    ARHGEF2 -->|"causes"| Midbrain_hindbrain_malformatio["Midbrain-hindbrain malformation"]
    ARHGEF2 -->|"activates"| Rac1["Rac1"]
    ARHGEF2 -->|"regulates"| Macropinocytosis["Macropinocytosis"]
    ARHGEF2 -->|"interacts"| CaMKK2["CaMKK2"]
    ARHGEF2 -->|"activates"| AMPK["AMPK"]
    ARHGEF2 -->|"activates"| MAPK_signaling["MAPK signaling"]
    PRDX1["PRDX1"] -->|"interacts"| ARHGEF2
    LMNA["LMNA"] -->|"interacts"| ARHGEF2
    IRF2BP2["IRF2BP2"] -->|"interacts"| ARHGEF2
    SQSTM1["SQSTM1"] -->|"interacts"| ARHGEF2
    NPM1["NPM1"] -->|"interacts"| ARHGEF2
    TPM3["TPM3"] -->|"interacts"| ARHGEF2
    RNA["RNA"] -->|"regulates"| ARHGEF2

Outgoing (35)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ARHGEF2	data_in	dataset_row	0.00
RhoA	activates	protein	0.90
Midbrain-hindbrain malformation	causes	phenotype	0.90
Intellectual disability	causes	disease	0.90
CaMKK2	interacts_with	protein	0.80
Rac1	activates	protein	0.80
Macropinocytosis	regulates	process	0.80
MAPK signaling	activates	pathway	0.80
AMPK	activates	protein	0.80
Tau	interacts_with	protein	0.70
Tumor	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
RNA	regulates	gene	0.60
IRF2BP2	interacts_with	gene	0.60
T Cell	regulates	cell_type	0.60
LMNA	associated_with	entity	0.60
NPM1	associated_with	entity	0.60
PRDX1	associated_with	entity	0.60
SQSTM1	associated_with	entity	0.60
TPM3	associated_with	entity	0.60
SQSTM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
NPM1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
Fus	interacts_with	protein	0.60
IRF2BP2	associated_with	gene	0.60
Myosin	regulates	protein	0.60
T Cell	expressed_in	cell_type	0.55
NTRK1	associated_with	protein	0.50
TPM3	associated_with	gene	0.50
PRDX1	associated_with	protein	0.50
NPM1	associated_with	gene	0.50
LMNA	associated_with	gene	0.50
SQSTM1	associated_with	gene	0.50

Incoming (8)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ARHGEF2	data_in	dataset_row	0.00
NPM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
PRDX1	interacts_with	gene	0.60
IRF2BP2	interacts_with	gene	0.60
RNA	regulates	gene	0.60
LMNA	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning arhgef2 in their description or question text

No additional research found