Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCT5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CCT5 |
| Full Name | Chaperonin Containing TCP1 Subunit 5 (Epsilon) |
| Chromosome | 5p15.2 |
| Protein Type | Chaperone |
| Function | The CCT5 gene encodes the epsilon subunit of the Chaperonin Containing TCP1 (CCT) complex, also known as TRiC (TCP-1 Ring Complex) |
| Molecular Weight | 56 kDa |
| Amino Acids | 535 aa |
| UniProt ID | P48643 |
| NCBI Gene ID | 1081 |
| Ensembl ID | ENSG00000116560 |
| OMIM | 604832 |
| GeneCards | CCT5 |
| Human Protein Atlas | CCT5 |
| Associated Diseases | Neuropathy |
| Interactions | NTRK1, RAB7, SPTLC1 |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CCT5"]
N1["Neuropathy"]
N0 -->|"associated with"| N1
N2["SPTLC1"]
N0 -->|"associated with"| N2
N3["RAB7"]
N0 -->|"associated with"| N3
N4["NGFR"]
N0 -->|"expressed in"| N4
N5["Neuron"]
N0 -->|"associated with"| N5
N6["Ngf"]
N0 -->|"associated with"| N6
N7["GENES"]
N7 -->|"associated with"| N0
N2 -->|"associated with"| N0
N3 -->|"associated with"| N0
N8["AND"]
N8 -->|"associated with"| N0
N4 -->|"expressed in"| N0
N0 -->|"expressed in"| N5
N0 -->|"interacts with"| N2
N0 -->|"interacts with"| N3
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N6 protein
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Neuropathy | associated_with | disease | 0.65 |
| Neuron | associated_with | cell_type | 0.60 |
| Ngf | associated_with | protein | 0.60 |
| SPTLC1 | associated_with | gene | 0.60 |
| RAB7 | associated_with | gene | 0.60 |
| NGFR | expressed_in | gene | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| RAB7 | interacts_with | gene | 0.50 |
| NTRK1 | interacts_with | protein | 0.50 |
| disease | interacts_with | disease | 0.50 |
| SPTLC1 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CCT5 in their description or question text
No additional research found