gene 640 words KG: NDUFA4
Contents

NDUFA4 Gene

🧬 Gene Info
Gene SymbolNDUFA4
Full NameNADH:Ubiquinone Oxidoreductase Subunit A4
Chromosome12p13.33
Protein TypeOxidoreductase
FunctionNDUFA4 (NADH:Ubiquinone Oxidoreductase Subunit A4) encodes a core subunit of mitochondrial Complex I (NADH:ubiquinone oxidoreductase), the largest enzyme of the mitochondrial electron transport chain.
Pathwaysunfolded protein response
UniProt IDNDUFA4
Ensembl IDENSG00000189090
GeneCardsNDUFA4
Human Protein AtlasNDUFA4
Associated DiseasesAls, Alzheimer
Known Drugs/Compoundsaducanumab
InteractionsCAPZB, CD81, COX4I1, CYCS, GDI2, NDUFS7
KG Connections40 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
CYP46A1 Overexpression Gene Therapy
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Mitochondria
entity · KG edge: interacts_with
CAPZB Gene
gene · KG edge: interacts_with
CD81
gene · KG edge: regulates

Knowledge Graph (12 edges)

CD81 regulates NDUFA4
GDI2 regulates NDUFA4
MAG regulates NDUFA4
HK1 regulates NDUFA4
PLCB1 regulates NDUFA4
NDUFS7 regulates NDUFA4
CAPZB regulates NDUFA4
NDUFA4 regulates MAG
NDUFA4 regulates PLCB1
NDUFA4 regulates CD81

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.