gene

MT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

1Hypotheses

0Analyses

13Outgoing

1Incoming

0Experiments

0Debates

Summary

MT3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, implicated in. Associated with Als, Alzheimer, Inflammation. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MT3
Full Name	Metallothionein-3
Chromosome	16q13
Protein Type	Metallothionein
Function	MT3 (Metallothionein 3), also known as Growth-Inhibitory Factor (GIF), is a metallothionein protein primarily expressed in the central nervous system.
Primary Expression	the central nervous system
Amino Acids	68 aa
Pathways	Metal Ion Homeostasis
UniProt ID	P07151
NCBI Gene ID	4502
Ensembl ID	ENSG00000125148
OMIM	157170
GeneCards	MT3
Human Protein Atlas	MT3
Associated Diseases	neurodegeneration
Interactions	INFLAMMATION, NEURODEGENERATION, P53
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MT3 — AlphaFold P07151 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MT3["MT3"]
    Tumor{"Tumor"}
    MT3 -->|"interacts_with"| Tumor
    Parkinson{"Parkinson"}
    MT3 -->|"regulates"| Parkinson
    Als{"Als"}
    MT3 -->|"interacts_with"| Als
    Inflammation{"Inflammation"}
    MT3 -->|"interacts_with"| Inflammation
    Alzheimer{"Alzheimer"}
    MT3 -->|"regulates"| Alzheimer
    Neurodegeneration{"Neurodegeneration"}
    MT3 -->|"interacts_with"| Neurodegeneration
    NEURODEGENERATION(["NEURODEGENERATION"])
    NEURODEGENERATION -->|"interacts_with"| MT3
    style MT3 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (13)

Target	Relation	Type	Str
Metal Ion Homeostasis	regulates	process	0.90
Parkinson	regulates	disease	0.65
Als	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Cell Cycle	interacts_with	pathway	0.60
ALZHEIMER	regulates	gene	0.60
P53	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
PARKINSON	regulates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
NEURODEGENERATION	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DNMT3A-Mediated de novo Methylation Corrects 'Epigenetic Sca	0.460	neurodegeneration	Investigate mechanisms of epigenetic rep

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MT3 in their description or question text

No additional research found

MT3