Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MOTOR CORTEX: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | MOTOR CORTEX |
| Key Genes/Proteins | C9orf72 |
| Related Diseases | ALS, AMYOTROPHIC LATERAL SCLEROSIS, ANGIOGENESIS, CEREBROSPINAL FLUID, CSF |
Knowledge base pages for this entity
graph TD
MOTOR_CORTEX[MOTOR CORTEX]
HUD[HUD] -->|expressed in| MOTOR_CORTEX
Dipeptide_Repeat_Proteins[Dipeptide Repeat Proteins] -->|expressed in| MOTOR_CORTEX
ALS[ALS] -->|expressed in| MOTOR_CORTEX
CHCHD2[CHCHD2] -->|expressed in| MOTOR_CORTEX
TDP_43[TDP-43] -->|expressed in| MOTOR_CORTEX
neurodegeneration[neurodegeneration] -->|affects| MOTOR_CORTEX
SST[SST] -->|expressed in| MOTOR_CORTEX| Target | Relation | Type | Str |
|---|---|---|---|
| ASTROCYTE | associated_with | cell_type | 0.50 |
| VEGF | associated_with | gene | 0.50 |
| TAU | associated_with | protein | 0.50 |
| CSF | associated_with | phenotype | 0.45 |
| TDP-43 | associated_with | gene | 0.45 |
| NEURONS | associated_with | cell_type | 0.45 |
| ALS | associated_with | disease | 0.45 |
| C9orf72 | associated_with | gene | 0.45 |
| FIBROBLASTS | associated_with | cell_type | 0.45 |
| NEURON | associated_with | cell_type | 0.45 |
| PARKINSON | associated_with | disease | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 24361077 | showed | paper | 0.90 |
| HUD | expressed_in | protein | 0.85 |
| Dipeptide Repeat Proteins | expressed_in | protein | 0.85 |
| ALS | expressed_in | gene | 0.80 |
| ALS | affects | disease | 0.80 |
| CHCHD2 | expressed_in | gene | 0.75 |
| TDP-43 | expressed_in | protein | 0.70 |
| TDP-43 | causes | protein | 0.70 |
| neurodegeneration | associated_with | process | 0.70 |
| neurodegeneration | affects | disease | 0.70 |
| ALS | produces | disease | 0.65 |
| PVALB | expressed_in | gene | 0.60 |
| SST | expressed_in | gene | 0.60 |
| VEGF | expressed_in | gene | 0.60 |
| Parkinson's disease | affects | disease | 0.60 |
| DNA | expressed_in | gene | 0.60 |
| ANGIOGENESIS | associated_with | phenotype | 0.50 |
| PYRAMIDAL NEURONS | associated_with | cell_type | 0.45 |
| PARKINSON'S DISEASE | associated_with | disease | 0.45 |
| CEREBROSPINAL FLUID | associated_with | phenotype | 0.45 |
| NEURODEGENERATION | associated_with | phenotype | 0.45 |
| INFLAMMATION | associated_with | phenotype | 0.45 |
| INTERNEURONS | associated_with | cell_type | 0.45 |
| MOTOR NEURONS | associated_with | cell_type | 0.45 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MOTOR CORTEX in their description or question text
No additional research found