protein

LYN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

15Outgoing

15Incoming

0Experiments

0Debates

Summary

Page for Lyn — Proto-Oncogene Tyrosine-Protein Kinase Lyn

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🔬 Protein Info

Gene Symbol	LYN
Chromosome	8q13.1.
Protein Type	Receptor
Function	LYN encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary Expression	hematopoietic cells and neuronal tissue[@ref]
Molecular Weight	56 kDa
Amino Acids	21 aa
Pathways	MAPK signaling, Oxidative Stress
Ensembl ID	ENSG00000101313
GeneCards	LYN
Human Protein Atlas	LYN
N-terminal myristoylation site	for membrane association
Unique domain	determines isoform specificity (LYN has two isoforms: p56 and p59)
SH3 and SH2 domains	for protein-protein interactions
Catalytic tyrosine kinase domain	for enzymatic activity
Associated Diseases	cancer
Interactions	ADRB2, AKT, AMPK, CD36, ERK1, FYN
KG Connections	30 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LYN Gene

gene · 764 words

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Pathway Diagram

graph TD
    LYN["LYN"]
    Inflammation{"Inflammation"}
    LYN -->|"inhibits"| Inflammation
    Als{"Als"}
    LYN -->|"inhibits"| Als
    Hepatitis{"Hepatitis"}
    LYN -->|"inhibits"| Hepatitis
    Ms{"Ms"}
    LYN -->|"therapeutic target"| Ms
    Cancer{"Cancer"}
    LYN -->|"regulates"| Cancer
    AMPK["AMPK"]
    LYN -->|"inhibits"| AMPK
    SRC["SRC"]
    LYN -->|"activates"| SRC
    neurodegeneration["neurodegeneration"]
    LYN -->|"implicated in"| neurodegeneration
    CD36["CD36"]
    CD36 -->|"inhibits"| LYN
    FYN["FYN"]
    FYN -->|"inhibits"| LYN
    FYN -->|"interacts with"| LYN
    SRC -->|"interacts with"| LYN
    ADRB2["ADRB2"]
    ADRB2 -->|"interacts with"| LYN
    GSK3B["GSK3B"]
    GSK3B -->|"interacts with"| LYN
    CANCER["CANCER"]
    CANCER -->|"regulates"| LYN
    style LYN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
duodenal cancer	amplified_in	disease	0.90
Ms	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
cancer	associated_with	disease	0.60
AMPK	inhibits	gene	0.60
SRC	activates	gene	0.60
ULK1	activates	gene	0.60
MAPK	associated_with	gene	0.60
MAPK signaling	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
Oxidative Stress	activates	pathway	0.60

Incoming (15)

Source	Relation	Type	Str
DST	associated_with	gene	0.60
CANCER	regulates	gene	0.60
CD36	inhibits	gene	0.60
FYN	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
FYN	interacts_with	gene	0.60
SRC	interacts_with	gene	0.60
ADRB2	interacts_with	gene	0.60
GSK3B	interacts_with	gene	0.60
JNK	inhibits	gene	0.60
ERK1	activates	gene	0.60
AKT	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LYN in their description or question text

No additional research found