protein

LDL RECEPTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDL RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

16Outgoing

15Incoming

0Experiments

0Debates

Summary

Page for LDL Receptor Protein

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🔬 Protein Info

Gene Symbol	LDL RECEPTOR
Amino Acids	40 aa
Pathways	Cholesterol
Associated Diseases	Alzheimer'S Disease, disease
Interactions	GPR146, LDLR
KG Connections	29 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    LDL_RECEPTOR["LDL RECEPTOR"]
    Proteins["Proteins"]
    LDL_RECEPTOR -->|"associated with"| Proteins
    ALZHEIMER["ALZHEIMER"]
    LDL_RECEPTOR -->|"associated with"| ALZHEIMER
    Alzheimer_S_Disease["Alzheimer'S Disease"]
    LDL_RECEPTOR -->|"associated with"| Alzheimer_S_Disease
    disease["disease"]
    LDL_RECEPTOR -->|"associated with"| disease
    ALZHEIMER_S["ALZHEIMER'S"]
    LDL_RECEPTOR -->|"associated with"| ALZHEIMER_S
    PCSK9["PCSK9"]
    LDL_RECEPTOR -->|"activates"| PCSK9
    Cholesterol["Cholesterol"]
    LDL_RECEPTOR -->|"inhibits"| Cholesterol
    atherosclerosis["atherosclerosis"]
    LDL_RECEPTOR -->|"inhibits"| atherosclerosis
    Macrophage["Macrophage"]
    LDL_RECEPTOR -->|"inhibits"| Macrophage
    MACROPHAGES["MACROPHAGES"]
    LDL_RECEPTOR -->|"inhibits"| MACROPHAGES
    Cholesterol["Cholesterol"]
    LDL_RECEPTOR -->|"expressed in"| Cholesterol
    atherosclerosis["atherosclerosis"]
    LDL_RECEPTOR -->|"expressed in"| atherosclerosis
    Macrophage["Macrophage"]
    LDL_RECEPTOR -->|"expressed in"| Macrophage
    MACROPHAGES["MACROPHAGES"]
    LDL_RECEPTOR -->|"expressed in"| MACROPHAGES
    APP_PS1["APP/PS1"]
    LDL_RECEPTOR -->|"inhibits"| APP_PS1
    Genes["Genes"]
    LDL_RECEPTOR -->|"associated with"| Genes
    VESICLE_TRAFFICKING["VESICLE TRAFFICKING"]
    LDL_RECEPTOR -->|"associated with"| VESICLE_TRAFFICKING
    LRP1["LRP1"]
    LRP1 -->|"associated with"| LDL_RECEPTOR
    LDLR["LDLR"]
    LDLR -->|"associated with"| LDL_RECEPTOR
    LRP4["LRP4"]
    LRP4 -->|"associated with"| LDL_RECEPTOR
    LRP8["LRP8"]
    LRP8 -->|"associated with"| LDL_RECEPTOR
    LRP5["LRP5"]
    LRP5 -->|"associated with"| LDL_RECEPTOR
    LRP1B["LRP1B"]
    LRP1B -->|"associated with"| LDL_RECEPTOR
    LRP2["LRP2"]
    LRP2 -->|"associated with"| LDL_RECEPTOR
    APOER2["APOER2"]
    APOER2 -->|"associated with"| LDL_RECEPTOR
    late["late"]
    late -->|"associated with"| LDL_RECEPTOR
    LDLR["LDLR"]
    LDLR -->|"activates"| LDL_RECEPTOR
    LDLR["LDLR"]
    LDLR -->|"inhibits"| LDL_RECEPTOR
    GPR146["GPR146"]
    GPR146 -->|"inhibits"| LDL_RECEPTOR
    FASN["FASN"]
    FASN -->|"associated with"| LDL_RECEPTOR

Outgoing (16)

Target	Relation	Type	Str
Proteins	associated_with	protein	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
atherosclerosis	inhibits	disease	0.50
Macrophage	inhibits	cell_type	0.50
MACROPHAGES	inhibits	concept	0.50
Cholesterol	expressed_in	pathway	0.50
atherosclerosis	expressed_in	disease	0.50
Macrophage	expressed_in	cell_type	0.50
MACROPHAGES	expressed_in	concept	0.50
APP/PS1	inhibits	concept	0.50
PCSK9	activates	concept	0.50
Cholesterol	inhibits	pathway	0.50
VESICLE TRAFFICKING	associated_with	concept	0.50

Incoming (15)

Source	Relation	Type	Str
APOE	binds	protein	0.90
APOE4	downregulates	protein	0.80
LDLR	activates	gene	0.50
LDLR	inhibits	gene	0.50
GPR146	inhibits	gene	0.50
LRP1	associated_with	gene	0.50
LDLR	associated_with	gene	0.50
LRP4	associated_with	gene	0.50
LRP8	associated_with	gene	0.50
LRP5	associated_with	gene	0.50
LRP1B	associated_with	gene	0.50
LRP2	associated_with	gene	0.50
APOER2	associated_with	protein	0.50
late	associated_with	disease	0.50
FASN	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LDL RECEPTOR in their description or question text

No additional research found